CHOLECYSTOKININ ANTAGONISTS

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 13848	Program Year/Program: 1990 / SBIR
Agency Tracking Number: 13848	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
View profile »

Woman-Owned: Yes

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 1990

Title: CHOLECYSTOKININ ANTAGONISTS

Agency: HHS

Contract: N/A

Award Amount: $50,000.00

Abstract:
POSSIBLE THERAPEUTICS FOR NEUROENDOCRINE AND GASTROINTESTINAL TUMORS AND NEUROPSYCHIATRIC DISEASES MAY BE DEVELOPED FROM PEPTIDE ANTAGONISTS OF THE CENTRAL NERVOUSSYSTEM CHOLECYSTOKININ RECEPTOR. STRUCTURALLY MODIFIED CHOLECYSTOKININ OCTAPEPTIDE FRAGMENTS WILL BE TESTED FOR INTERACTION WITH CHOLECYSTOKININ RECEPTORS IN A NEUROENDOCRINE CELL LINE, HUMAN SMALL-CELL LUNG CARCINOMA. THESE COMPOUNDS, MORE CLOSELY RESEMBLING NATURALLY OCCURRINGNEUROPEPTIDES, SHOULD CROSS-REACT LESS WITH OTHER CENTRAL NERVOUS SYSTEM RECEPTORS, RESULTING IN FEWER UNDESIRABLE SIDE EFFECTS. POTENT COMPOUNDS IDENTIFIED IN THE CELL ASSAYWILL BE FURTHER EVALUATED IN PHARMACOLOGICAL PRECLINICAL STUDIES IN THE PHASE II RESEARCH.

Principal Investigator:
Martha Knight
2022343384

Business Contact:

Small Business Information at Submission:

Peptide Technologies Corp
125 Michigan Ave Ne #368 Main Washington, DC 20017

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No