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CHOLECYSTOKININ ANTAGONISTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13848
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13848
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptide Technolgies Corp.
PO BOX 368 MAIN 125 MICHIGAN AVE NE Washington, DC 20017
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: CHOLECYSTOKININ ANTAGONISTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

POSSIBLE THERAPEUTICS FOR NEUROENDOCRINE AND GASTROINTESTINAL TUMORS AND NEUROPSYCHIATRIC DISEASES MAY BE DEVELOPED FROM PEPTIDE ANTAGONISTS OF THE CENTRAL NERVOUSSYSTEM CHOLECYSTOKININ RECEPTOR. STRUCTURALLY MODIFIED CHOLECYSTOKININ OCTAPEPTIDE FRAGMENTS WILL BE TESTED FOR INTERACTION WITH CHOLECYSTOKININ RECEPTORS IN A NEUROENDOCRINE CELL LINE, HUMAN SMALL-CELL LUNG CARCINOMA. THESE COMPOUNDS, MORE CLOSELY RESEMBLING NATURALLY OCCURRINGNEUROPEPTIDES, SHOULD CROSS-REACT LESS WITH OTHER CENTRAL NERVOUS SYSTEM RECEPTORS, RESULTING IN FEWER UNDESIRABLE SIDE EFFECTS. POTENT COMPOUNDS IDENTIFIED IN THE CELL ASSAYWILL BE FURTHER EVALUATED IN PHARMACOLOGICAL PRECLINICAL STUDIES IN THE PHASE II RESEARCH.

Principal Investigator:

Martha Knight
2022343384

Business Contact:

Small Business Information at Submission:

Peptide Technologies Corp
125 Michigan Ave Ne #368 Main Washington, DC 20017

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No