USA flag logo/image

An Official Website of the United States Government

MEMBRANE BASED PEPTIDE SYNTHESIS

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
14379
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
14379
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PEPTIDES INTERNATIONAL, INC.
PEPTIDES INTERNATIONAL, INC. 11621 ELECTRON DR LOUISVILLE, KY 40299-3861
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: MEMBRANE BASED PEPTIDE SYNTHESIS
Agency: NSF
Contract: N/A
Award Amount: $46,500.00
 

Abstract:

MICROPOROUS MEMBRANES ARE USED IN A VARIETY OF SUPPORT FUNCTIONS, RANGING FROM PARTICLE FILTRATION TO AFFINITY LIGAND MEDIA. THEY PROVIDE A LARGE EXTENDED SURFACE THAT ISRAPIDLY ACCESSIBLE BY VIRTUE OF CONVECTIVE FLOW THROUGH THEIR PORE STRUCTURE. SUCH CONVECTIVE FLOW OFFERS THE POSSIBILITY OF MUCH MORE RAPID REACTIONS OR COMPLEXATION WHEN COMPARED TO PROCESSES LIMITED BY DIFFUSION. IN THE PREPARATION OF SYNTHETIC PEPTIDES THE USE OF MICROPOROUS MEDIA IN BEAD FORM IS WELL ESTABLISHED. HOWEVER, DELIVERY OF REAGENTS, REMOVAL OF BY-PRODUCTS, AND REACTIVATION OF INTERMEDIATES ARE ALL DIFFUSION DEPENDENT WHEN SUCH MEDIA ARE USED. FOR CERTAIN APPLICATIONS THIS DIFFUSIVE CONTROL MITIGATES BOTH PRODUCT PURITY AND SCALE-UP POTENTIAL. WE PROPOSE TO STUDY THE FEASIBILITY OF MEMBRANE BASED PEPTIDE SYNTHESIS (MBPS) BY A CAREFULLY CONTROLLED SERIES OF MODEL PEPTIDE PREPARATION ON SEVERAL FUNCTIONALIZED MEMBRANE SUPPORTS. DURING PHASE I WE WILL DETERMINE THE MOST APPROPRIATE LINKAGE CHEMISTRIES, SELECT APPROPRIATE SOLVENT(S) AND SURVEY THE MOST PROMISING MICROPOROUS MEMBRANE MATERIALS FOR THEIR UTILITY. THIS PHASE WILL CULMINATE IN THE DEMONSTRATED SYNTHESIS OF A PEPTIDE ON THE MEMBRANE SUPPORT AND DETERMINATION OF ITS STRUCTURAL INTEGRITY.

Principal Investigator:

Deanne Benovitz
Sr. Technical Representative
0

Business Contact:

Small Business Information at Submission:

Peptides International Inc
10101 Linn Station Rd Louisville, KY 40223

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No