DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is a highly morbid, autosomal recessive disease caused by one or more mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The CFTR protein is important in transporting sodium and chloride… More

DESCRIPTION (provided by applicant): PharmaSeq provides ultra-small microtransponders and a fluidics-based, bench-top flow reader as tools to perform complex bioassays. The assay involves three phases: conjugation or synthesis of probe molecules on the microtransponder surface, the binding reaction… More

DESCRIPTION (provided by applicant): It is proposed to develop a multiplex cytotoxicity assay on electronic microchips, microtransponders. Each microtransponder is composed of photocells, antenna and memory to store information that identifies the specific features of the biological material,… More

DESCRIPTION (provided by applicant): We propose to develop a fluidics-based automated sorter for microtransponders to complement the existing line of PharmaSeq instruments and reagents. PharmaSeq provides ultra-small light-powered microtransponders and a fluidics-based bench-top flow reader as tools… More

DESCRIPTION (provided by applicant): PharmaSeq provides ultra-small micro transponders and a fluidics-based, bench-top flow reader as tools to perform complex bioassays. A micro transponder is an integrated circuit with an electronically stored ID (64 bits) and the capability to transmit the ID by… More

DESCRIPTION (provided by applicant): We propose to conduct a clinical study of an in vitro diagnostic system capable of detecting mutations in the gene related to cystic fibrosis (CFTR). The system consists of the cystic fibrosis DNA-based assay and suppo rting instrumentation. The assay was… More

DESCRIPTION (provided by applicant): The main goal of the project is to increase sensitivity of the microtransponder-based multiplexed bioassays by (1) introducing a coating with silver nanostructures onto the microtransponders (MTPs) to enhance fluorescen ce, and (2) improving the fluorescence… More

This Phase I project aims to develop a technology to simultaneously measure three biomarkders for early prostate cancer detection using an electronic radio frequency (RF) light-powered microtransponder. Antigens will be captured using antibodies coupled to the microtransponders and detected using… More

DESCRIPTION (provided by applicant): The purpose of the present project is to develop a new type of RFID tagging system for tracking laboratory mice. It is based on the PharmaSeq laser light-powered microtransponder. Its major advantages are its small size (500 5m x 500 5m x 100 5m), monolithic… More

DESCRIPTION (provided by applicant): The main goal of the project is to increase the sensitivity of microtransponder-based multiplexed bioassays by (1) introducing a coating with silver nanostructures onto the microtransponders (MTPs) to enhance fluorescen ce emission, and (2) improving the… More

DESCRIPTION (provided by applicant): The purpose of the present project is to develop a new type of RFID tagging system for tracking mice. It is based on the PharmaSeq laser light-activated microtransponder, also known as p-Chip . Its major advantages are its small size (500 5m x 500 5m x 100 5m),… More

DESCRIPTION (provided by applicant): The purpose of the present project is to demonstrate the feasibility of using a novel RFID chip to tag and track tissue cassettes and glass slides that are used in histopathology laboratories. The system is based on thePharmaSeq laser light-activated… More

DESCRIPTION (provided by applicant): The purpose of the present project is to develop and validate the use of ultra-small RFID chips to tag and track tissue cassettes and glass slides that are used in histopathology laboratories. The system is based on thePharmaSeq laser light-activated… More

DESCRIPTION (provided by applicant): The development of circulating auto-antibodies to tumor-associated antigens (TAAs) has been observed at early cancer stages. TAA auto-antibodies are attractive as diagnostic markers because they are stable and persistent in cancerous conditions yet minimally… More

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its… More

The project is aimed at the development of a cost effective, serum-based multiplex assay for early detection of clinically significant forms of prostate cancer. The assay utilizes metal-enhanced flourescence to provide an ultra-sensitive immunoassay for three cancer markers: alpha-methylacyl… More