Award Year / Program / Phase:1999 / SBIR / Phase I
Agency:HHS
Principal Investigator:Mike A. Clark
Award Amount:$100,492.00
Abstract:
Not Available A novel high temperature inductive turbine blade tip clearance sensor is proposed to meet the needs indicated by the Air Force and corroborated by several turbine manufacturers for research and development as well as production applications. The design will meet the goals of measuring… More
Award Year / Program / Phase:2001 / SBIR / Phase I
Agency:HHS
Principal Investigator:Mike A. Clark
Award Amount:$0.00
Abstract:
DESCRIPTION: The distinctive arginine requirement of hepatocellular carcinomas
and malignant melanomas provides the basis for a new potential chemotherapy.
Just as acute lymphocytic leukemia cells require asparagine and E. coli
asparaginase enzyme can be used to effect a… More
Award Year / Program / Phase:2001 / SBIR / Phase II
Agency:HHS
Principal Investigator:Mike A. Clark
Award Amount:$383,600.00
Abstract:
DESCRIPTION: The distinctive arginine requirement of hepatocellular carcinomas
and malignant melanomas provides the basis for a new potential chemotherapy.
Just as acute lymphocytic leukemia cells require asparagine and E. coli
asparaginase enzyme can be used to effect a… More
Award Year / Program / Phase:2001 / SBIR / Phase I
Agency:HHS
Principal Investigator:Mike A. Clark
Award Amount:$99,962.00
Abstract:
DESCRIPTION (PROVIDED BY APPLICANT): The long-term goal of the proposed
research is the development of effective anti-cancer agents, modified human
tumor necrosis factor-alphas (hTNFas). TNFa is a potent anti-neoplastic agent
but its therapeutic application has been… More
Hyperuricemia (elevated serum uric acid) results in gouty arthritis and chronic renal disease. Severe hyperuricemia can occur following cancer chemotherapy (tumor lysis syndrome) and organ transplantation (most common in heart and kidney transplant patients) which may result in acute uric acid… More
DESCRIPTION (provided by applicant): Unformulated human tumor necrosis factor( (huTNF() has anti-tumor activity in mice, but there is little difference between the effective and lethal doses. Systemic administration of unformulated huTNFalpha has been tested in humans. All studies indicated the… More
DESCRIPTION (provided by applicant): Unformulated human tumor necrosis factor( (huTNF() has anti-tumor activity in mice, but there is little difference between the effective and lethal doses. Systemic administration of unformulated huTNFalpha has been tested in humans. All studies indicated the… More