Reference: national institute of mental health design and implementation of a software program to provide automated real time acquisition and analysis of in vivo 31 phosphorous nuclear magnetic resonance spectra from the brains of neonates. this will permit the prediction or identification of life… More

This proposal is to construct and test a laboratory prototype isolette for preterm infants appropriate to the phosphorous nmr examination of their organ biochemistry (brain, kidney, liver, and skeletal tissue). this isolette is designed to provide a safe and comfortable life-support environment for… More

Design and construction of a 3.0 tesla high-resolution superconducting magnet system with short horizontal 30cm bore to incorporate with phospho-energetics, preliminary work has been performed at the university of pennsylvania department of biochemistry using 1.5 and 1.9 tesla superconducting… More

This proposal describes a new method for stabilizing the energy state of the brain that is threatened by hypoxic distress due to failure of adequate o2 delivery. the energy state of the brain is evaluated by 31p nmr every 2 to 4 minutes and the ratio of phosphocreatine (pcr) to inorganic phosphate… More

The three-dimensional visualization of organs and tissues by proton nuclear magnetic resonance has been possible for several years, and now activity is directed towards visualization of other nuclei, such as phosphorus and sodium and constituents of hydrogen-containing molecules such as lactate… More

This project will address (1) a new method for evaluating the nutritional status of patients, (2) the adequacy of parenteral nutrition therapy, (3) new formulations of nitrogen-containing parenteral nutrition fluids, (4) the achievement of redox balance within the organs to which the new… More

Phospho-energetics, inc. (p-e) has developed an nmr spectro-meter for the validation of 31p in diseased and normal humantissues; based upon that process, p-e has now developed a combination nmr/work output measuring instrument. studies have been performed with subjects suffering from peripheral… More