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THIS PROPOSAL DESCRIBES A NEW METHOD FOR STABILIZING THE ENERGY STATE OF THE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3298
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3298
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Phospho-energetics Inc.
3401 Market Street Suite 320 Philadelphia, PA 19104
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THIS PROPOSAL DESCRIBES A NEW METHOD FOR STABILIZING THE ENERGY STATE OF THE BRAIN THAT IS THREATENED BY HYPOXIC DISTRESS DUE TO FAILURE OF ADEQUATE O2 DELIVERY.
Agency: HHS
Contract: N/A
Award Amount: $49,484.00
 

Abstract:

THIS PROPOSAL DESCRIBES A NEW METHOD FOR STABILIZING THE ENERGY STATE OF THE BRAIN THAT IS THREATENED BY HYPOXIC DISTRESS DUE TO FAILURE OF ADEQUATE O2 DELIVERY. THE ENERGY STATE OF THE BRAIN IS EVALUATED BY 31P NMR EVERY 2 TO 4 MINUTES AND THE RATIO OF PHOSPHOCREATINE (PCR) TO INORGANIC PHOSPHATE (PI) OR TO ADENOSINE TRIPHOSPHATE (ATP) IS EMPLOYED AS A QUANTITATIVE MEASURE OF THIS ENERGY STATE. MODEL STUDIES SHOW THAT VALUES FOR PCR/PI ABOVE 1.0 AFFORD STABLE FUNCTION OF BRAIN (AND HEART) METABOLISM AND VALUES BELOW 1.0 APPEAR TO BE INSUFFICIENT FOR LONG-TERM ORGAN SURVIVAL. VARIATION OF THE OXYGEN DELIVERED TO THE TISSUES (FIO2) WILL CONTROL THIS RATIO PARTICULARLY IN CASES OF INSUFFICIENT LUNG FUNCTION AS IN RESPIRATORY DISTRESSED NEONATES, BUT NOT LIMITED THERETO. THE SPECIFIC PROPOSAL FOR PHASE I INVOLVES THE TESTING OF THE MANUAL CONTROL OF FIO2 IN RESPONSE TO THE NEED FOR HEART OR BRAIN PCR/PI VALUES THAT ARE ABOVE 1.0, FIRST IN ANIMAL MODELS, SECONDARILY (PHASES I AND II) IN RESPIRATORY DISTRESSED NEONATES AND, AS LARGER MAGNETS BECOME AVAILABLE, IN ADULTS WHO REQUIRE OXYGEN THERAPY. SERVO CONTROL OF THE BRAIN OR HEART ENERGY STATE IS DESCRIBED AND REPRESENTS THE SECOND PHASE (II) OF DEVELOPMENT THAT AFFORDS AN AUTOMATIC CONTROL AND PRESENTATION OF EVEN MOMENTARY LOSS OF ORGAN ENERGY STATES IN PATIENTS WITH DISEASES OF O2 DELIVERY TO TISSUE.

Principal Investigator:

Roger wheatley
PRINCIPAL INVESTIGATOR
2153874429

Business Contact:

Small Business Information at Submission:

Phosphoenergetics, Inc.
3401 Market St., Rm. 320 Philadelphia, PA 19104

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No