USA flag logo/image

An Official Website of the United States Government

Retinal Oximeter for Clinical Assessments

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65579
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
EY014776
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PHOTON INDUSTRIES
PHOTON INDUSTRIES BLDG 9313, RM 167 STENNIS SPACE CENTER, MS 39529
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Retinal Oximeter for Clinical Assessments
Agency: HHS
Contract: 1R43EY014776-01
Award Amount: $111,289.00
 

Abstract:

DESCRIPTION (provided by applicant): In this SBIR we propose to develop a retinal vessel oxygen saturation monitoring system for investigational and clinical use. Retinal oximetry has been the subject of intense research and development since Hickam et al published the first photographic means in 1963. Studies of the retinal circulation and oxygen saturation have implicated oxygen status in diseases of the retina, including vein occlusion, diabetic retinopathy, glaucoma and optic atrophy. Oximetry studies have shown impairment of retinal blood flow regulation in diabetes and improvement in retinal oxygenation by pan-retinal photocoagulation treatment for proliferative diabetic retinopathy. Recently, studies have used imaging oximetry technique to evaluate side effects of glaucoma medications on retinal oxygenation. Thus, there is growing interest in retinal oximetry for monitoring retinal pathology. We propose here to develop an instrument we call OXYCAM for determining changes in oxygenation from distinct regions of the retina. This ability to detect subtle changes will be important in preventing the blinding complications of retinovascular disease. The long-term objectives of this project are 1) to make available a standardized commercial system for oximetric evaluation of retinal disease in research institutions and clinics and 2) to determine the role of oximetry as a retinal evaluation tool, which will lead to a commercial market for oximetry products. The specific aims of Phase I include 1) development of the dual-wavelength OXYCAM Imaging system for oximetric assessment at different levels of the retinal circulation and 2) validation of the OXYCAM performance in normal subjects. Coverage of retinal vessel networks in single dual-wavelength recordings will be achieved with pairs of large-format CCD sensors and a dichroic image splitter. Our longer term aims in Phase II include 1) development of automated vessel tracking and oximetry analysis software, 2) refinement of oximetry technique to improve accuracy and reproducibility in clinical work and 3) multi-site investigations into the role of oximetry in diagnosis, management and treatment of retinal disease.

Principal Investigator:

James M. Beach
5044121200
EADEAE@AOL.COM

Business Contact:


2286898176
Small Business Information at Submission:

PHOTON INDUSTRIES
PHOTON INDUSTRIES BLDG 9313, RM 167 STENNIS SPACE CENTER, MS 39529

EIN/Tax ID: 223861880
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No