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Immunotoxicity Monitoring Method for Unknown Noxious Exposures (IMMUNE)

Award Information

Agency:
Department of Defense
Branch:
Air Force
Award ID:
72883
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
F051-076-1534
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Physical Sciences Inc.
20 New England Business Center Andover, MA 01810-1077
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Immunotoxicity Monitoring Method for Unknown Noxious Exposures (IMMUNE)
Agency / Branch: DOD / USAF
Contract: FA8650-05-M-6603
Award Amount: $99,997.00
 

Abstract:

In this proposal we describe the development of a technology (nanoCyl) that can assay multiple protein biomarkers in small sample volume physiological fluids. It offers the potential for a novel immune assessment tool that can be deployed in the field for the rapid assessment of exposure of troops to a wide range of toxic agents. Proof of concept for the technology will be provided through the measurement of cytokine/chemokine expression profiles that characterize the immune system response to respiratory tract pathogens, through collaboration with Dr. Wayne Ensign of the Naval Health Research Center. A model profiling system will be demonstrated that will assay TNF-alpha and IL-1beta with an analyte detection sensitivity of < 10 pg/ml and a coefficient of variation of < 20%. This detection sensitivity is consistent with the changes in TNF-alpha and IL-1beta levels secreted into sputum. A subsequent Phase II project would involve the development of a prototype system suitable for deployment in the field.

Principal Investigator:

Mitchell R. Zakin
Area Manager, Life Sciences
9786890003
zakin@psicorp.com

Business Contact:

B. D. Green
President, PSI R&D Operations
9786890003
green@psicorp.com
Small Business Information at Submission:

PHYSICAL SCIENCES, INC.
20 New England Business Center Andover, MA 01810

EIN/Tax ID: 042517090
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No