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DESIGNER RAT MODELS THAT MIMIC TYPE 2 DIABETES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60881
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
DK061788
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PHYSIOGENIX, INC.
PHYSIOGENIX, INC. 10437 INNOVATION DR, STE 325 WAUWATOSA, WI 53226-4838
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: DESIGNER RAT MODELS THAT MIMIC TYPE 2 DIABETES
Agency: HHS
Contract: 1R43DK061788-01
Award Amount: $489,659.00
 

Abstract:

This SBIR Phase I project will employ a new bioinformatic tool to combine in silico gene mapping and comparative genomics for predicting designer rat strains that mimic human disease. The genome sequencing projects are bringing new molecular tools to both the pharmacologist and toxicologist. However, each species has its own biological foundations that may lead to misclassification of drug efficacy resulting in the high failure rates of compounds late in clinical trials. Therefore, a need exists within the pharmaceutical and academic communities for more precise animal model systems that better reflect the specific components of a clinically defined disease. PhysioGenix, Inc. will accomplish this by matching the traits of human diseases to a panel of designer rat strains at both the phenotypic and genomic levels (note that this is a paradigm shift from the standard practice of matching animal models to human diseases based solely on phenotype). Proof of principle will be demonstrated by phenotyping designer rats modeled for type 2 diabetes and show that strains like these will be ideal for drug screening, gene discovery and molecular target validation. Phase II efforts will expand the designer rat panel to mimic different diseases and contribute to PhysioGenix' knowledge warehouse.

Principal Investigator:

Steven H. Nye
4147717469
SNYE@PHYSIOGENIX.COM

Business Contact:

Howard Jacob
4143057469
JACOB@MCW.EDU
Small Business Information at Submission:

PHYSIOGENIX, INC.
PHYSIOGENIX, INC. 10437 INNOVATION DR, STE 329 MILWAUKEE, WI 53226

EIN/Tax ID: 391906674
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No