USA flag logo/image

An Official Website of the United States Government

Combinatorial rat panels that genetically screen anthrax

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66024
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI053959
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PHYSIOGENIX, INC.
PHYSIOGENIX, INC. 10437 INNOVATION DR, STE 325 WAUWATOSA, WI 53226-4838
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Combinatorial rat panels that genetically screen anthrax
Agency: HHS
Contract: 1R43AI053959-01
Award Amount: $312,536.00
 

Abstract:

DESCRIPTION (provided by applicant): The recent anthrax-related events have revealed the need to fill gaps in the knowledge base that compromise our response to a bioterrorist attack using Category A pathogens like Bacillus anthracis. As with most biological systems, there is tremendous diversity in response to pathogens. This SBIR Phase I project will test for diversity in host response to anthrax lethal toxin (LeTx). The investigators will identify and incorporate this diversity into a PathoGenix panel to: (1) mimic a genetically diverse, human population as the target in a bioterrorist attack; (2) be used as a sensitive screen for susceptible genotypes; and (3) identify intracellular pathways for therapeutic intervention. First, candidate rat strains will be selected based on the haplotype of anthrax-related genes using in silico tools. Second, in vivo and in vitro susceptibility to anthrax LeTx will be quantified followed by establishment of combinatorial breeding pairs. Third, the effects of LeTx will be measured in the panel, which enables localization of the gene region responsible for resistance or susceptibility. Decoding these data will begin to define the genomic contribution of the host-pathogen relationship. The goal in this project is to validate a new panel of rats for detecting the genetic effects of anthrax LeTx.

Principal Investigator:

Steven H. Nye
4144316600
SNYE@PHYSIOGENIX.COM

Business Contact:

Howard Jacob
4143057465
Small Business Information at Submission:

PHYSIOGENIX, INC.
PHYSIOGENIX, INC. 10437 INNOVATION DR, STE 325 WAUWATOSA, WI 53226

EIN/Tax ID: 391906674
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No