This Small Business Innovation Research (SBIR) Phase I project will initiate the development of an entirely new class of biochips, with a particular focus on biochips designed to track the expression, activation and post-translational modification of proteins involved in cell signaling processes.… More

DESCRIPTION (provided by applicant): The 1996 Food Quality Protection act mandates a re-evaluation of the risks of long-term exposure of individuals,… More

DESCRIPTION (provided by applicant):The investigation of an epizootic presents the challenge of detecting antibodies in multiple species. ELISA, the method commonly used for screening large numbers of samples for antibodies, requires species-specific secondary antibodies. In the… More

DESCRIPTION (provided by applicant): Platypus technology is a radically different approach to the detection and simultaneous identification of viruses. The platform technology is based on new principles of biophotonics that permit amplification and transduction of… More

Platypus/TM/ technology is a novel, platform technology for the detection of molecular interactions. It is based on the exquisite sensitivity of liquid crystals to nano-scale features on surfaces. It can be used for the detection of a wide range of target molecules. It's advantages are: simplicity,… More

Key cell signaling molecules, such as Ras, play a central role in carcinogenesis and are the targets for a new generation of drugs that inhibit protein kinases. The ability to measure the activation status of molecules along an entire pathway is of increasing importance, yet the available… More

This Small Business Innovation Research (SBIR) Phase II project proposes to develop an entirely new class of biochips, with a particular focus on biochips designed to track the expression, activation and post-translational modification of proteins involved in cell signaling processes. The technology… More

This Small Business Innovation Research (SBIR) Phase II project proposes to develop an entirely new class of biochips, with a particular focus on biochips designed to track the expression, activation and post-translational modification of proteins involved in cell signaling processes. The technology… More

DESCRIPTION (provided by applicant): The long-term goal of this Phase I SBIR is to develop optimized components (nanostructured substrates) for use in the creation of a novel class of rapid, liquid crystal based cellular assays of enumeration, proliferation and function. There is a need for new… More

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a passive monitor for measurement of cumulative exposure to organophosphate (OP) pesticides. This monitor is based on the innovative exploitation of the anchoring of liquid crystals to a surface functionalized with… More

DESCRIPTION (provided by applicant): The long-term goal of this Phase 1 SBIR is to develop optimized components (nanostructured substrates) and methods for use in the creation of a novel class of rapid, liquid crystal based assays capable of reporting enzyme activity. This proposal focuses on the… More

DESCRIPTION (provided by applicant): Our goal in this Phase 2 SBIR proposal is to develop and optimize the components for a novel cell migration assay. In Phase 1, we demonstrated that liquid crystals assume a predictable orientation in response to cellular membranes, and therefore they could be… More

DESCRIPTION (provided by applicant): We propose to pursue the development of a novel, rapid (

DESCRIPTION (provided by applicant): Liquid crystals can be used to image proteins on surfaces. In previous studies, we have shown that a combination of affinity contact printing techniques with liquid crystal imaging can form the basis for a rapid, label free detection technology, useful in the… More

DESCRIPTION (provided by applicant): Quantitative monitoring of personal exposure to environmental toxins is currently limited by expense, inconvenience and lack of appropriate technology, yet such monitoring is needed for investigation of health effects caused by low dose, chronic exposure to… More

DESCRIPTION (provided by applicant) The goal of this project is to develop a GPS-enabled multi-analyte sensor that can detect and measure exposure to trace gases present in air, specifically ozone, carbon monoxide and carbon dioxide gases. This sens or is based on the innovative exploitation… More

DESCRIPTION (provided by applicant): Viral hepatitis is a global public health issue. It is estimated that in the United States 3 million people are infected with hepatitis C virus and do not know it. The prognosis, treatment and response to treatment of h epatitis vary with the causative viral… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a liquid crystal-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits th e sensitivity of liquid crystals (LCs) to… More

DESCRIPTION (provided by applicant): The long term goal of this project is to develop a 384-well plate-based cell migration assay suitable for high throughput screening (HTS) of chemical libraries. The principal barrier to performing HTS to discover cancer drugs affecting cell migration is the lack… More

DESCRIPTION (provided by applicant): The long term goal of this project is to develop a 384-well cell invasion assay suitable for high throughput screening (HTS) of chemical libraries. The principal barrier to evaluating cancer drugs for cell invasion is the lack of affordable 3-dimensional assays… More

DESCRIPTION (provided by applicant): Workers in painting, automobile, textile, printing, and pharmaceutical industries are exposed to vapors from organic solvents that are recognized by National Institute of Occupational Safety and Hygiene (NIOSH) as carcinogens, reproductive hazards, and/or… More

This Small Business Innovation Research (SBIR) Phase I project will lead to the development of a new class of liquid crystal (LC)-based direct-read monitors (DRMs) for detection of nitrogen dioxide (NO2) present in air at construction sites. The approach to development of DRMs that is described in… More