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Rapid Liquid Crystal Detection of Ras

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Platypus Technologies, LLC
5520 Nobel Drive Suite 100 MADISON, WI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2005
Title: Rapid Liquid Crystal Detection of Ras
Agency: HHS
Contract: 1R43CA117215-01
Award Amount: $200,000.00


DESCRIPTION (provided by applicant): We propose to pursue the development of a novel, rapid (<30 min) exquisitely sensitive (femtogram), label-free platform technology using liquid crystals for the quantification of Ras, a key signaling protein. In this proposal, we will develop a method for the rapid capture of Ras from solution onto micro or nano-sized magnetic particles and then detect the captured Ras on nanostructured surfaces using liquid crystals. The approach involves direct detection of Ras, does not require secondary antibodies, and will permit rapid detection of low concentrations of proteins in small sample volumes, such as tumor cell lysates. In Phase 2, we will expand the technology to detection of other signaling proteins as well as simultaneous determination of their state of activation. The elements of this technology are readily adaptable to high throughput systems suitable for the identification and development of therapeutic compounds through an understanding of their action on cell signaling pathways.

Principal Investigator:

Barbara A. Israel

Business Contact:

Susan Pschorr
Small Business Information at Submission:

Platypus Technologies, LLC
Platypus Technologies, Llc 5520 Nobel Drive, Suite 100 Madison, WI 53711

EIN/Tax ID: 391992935
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No