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Improved Sensitivity in a Rapid, Label-Free Immunoassay using Liquid Crystals

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80237
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
GM077811
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Platypus Technologies, LLC
5520 Nobel Drive Suite 100 MADISON, WI 53711-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Improved Sensitivity in a Rapid, Label-Free Immunoassay using Liquid Crystals
Agency: HHS
Contract: 1R43GM077811-01
Award Amount: $453,621.00
 

Abstract:

DESCRIPTION (provided by applicant): Liquid crystals can be used to image proteins on surfaces. In previous studies, we have shown that a combination of affinity contact printing techniques with liquid crystal imaging can form the basis for a rapid, label free detection technology, useful in the detection of antibodies. In this Phase 1 proposal, we undertake to increase the sensitivity of this approach to extend its usefulness to detection of low concentration molecules of clinical relevance, such as biomarkers and cytokines. We propose approaches that will permit detection of molecules present in solution at the pg/ml concentration. The success of this project will permit the development of high sensitivity, high density micro arrays based on liquid crystals for rapid, label free detection of low concentration molecules.

Principal Investigator:

Barbara A. Israel
6082371270
bisrael@platypustech.com

Business Contact:

Susan Pschorr
6082371272
SPSCHORR@PLATYPUSTECH.COM
Small Business Information at Submission:

PLATYPUS TECHNOLOGIES, LLC
PLATYPUS TECHNOLOGIES, LLC 5520 Nobel Drive, Suite 100 MADISON, WI 53711

EIN/Tax ID: 391992935
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No