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LC-based Nitric Oxide Breath Monitor for Asthma Management

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93932
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
HL095167
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
PLATYPUS TECHNOLOGIES, LLC
5520 Nobel Drive Suite 100 Madison, WI 53711-4910
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: LC-based Nitric Oxide Breath Monitor for Asthma Management
Agency: HHS
Contract: 1R43HL095167-01
Award Amount: $399,939.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of this project is to develop a liquid crystal-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits th e sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfaces. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to det ect selected compounds. Because the technology does not require expensive or complex instrumentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of exhaled nitric oxide. The LC-based sensor elements are small (lt1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management. PUBLIC HEALTH RELEVANCE: The goal of this project is to develop a liquid crysta l-based sensor that can detect and measure nitric oxide in exhaled breath. The sensor technology is based on a broadly applicable detection platform that exploits the sensitivity of liquid crystals (LCs) to the nanoscopic changes in the structure of surfac es. Many attributes of this LC technology suggest that it offers exciting potential for clinical applications. It can be used to fabricate low cost, highly specific sensor elements that analyze chemicals in real time (response in ~ 10 seconds), are highly sensitive (can detect 1 ppb or less in vapor phase), provide a wide dynamic range (4 orders of magnitude), offer format flexibility, and are easily customized to detect selected compounds. Because the technology does not require expensive or complex instru mentation, or highly skilled personnel to operate the equipment, it is ideally suited as a cost-effective and reliable approach for breath monitoring. The outcome of this Phase I proposal will be a sensor element that can detect and measure ppb levels of e xhaled nitric oxide. The LC-based sensor elements are small (lt1cm in size) and will be integrated with electronics to analyze and report analyte concentrations. Our intended product will display a readout of the collected data to the user. Such a product will enable self- monitoring by asthmatics and play a key role in disease management.

Principal Investigator:

Avijit Sen
6082371270
ASEN@PLATYPUSTECH.COM

Business Contact:

Renee Herber
rherber@platypustech.com
Small Business Information at Submission:

PLATYPUS TECHNOLOGIES, LLC
5520 Nobel Drive Suite 100 MADISON, WI 53711

EIN/Tax ID: 391992935
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No