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Cell Density Monitor in Disposable Bag MoAb Bioreactors

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70683
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
CA108223
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Polestar Technologies Inc.
220-3 Reservoir Street Needham Heights, MA 02494-3133
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Cell Density Monitor in Disposable Bag MoAb Bioreactors
Agency: HHS
Contract: 1R43CA108223-01
Award Amount: $86,570.00
 

Abstract:

DESCRIPTION (provided by applicant): There is a need for an in-situ cell density monitor to provide continuous measurement of mammalian cell density inside of disposable, pre-sterilized bag bioreactors which have become an important new type of cell culture vessel for the production of monoclonal antibodies. Cell density is a key parameter for cell culture process diagnostic and optimization purposes. At present there is no available instrumentation for monitoring cell density in disposable bag bioreactors. The new optically based cell density measurement approach provides a simple and reliable method for in situ monitoring cell density inside of plastic bag bioreactors. The measurement approach can also be applied to other types of cell culture vessels including spinner flasks, T-flasks, and roller bottles that are also used grow mammalian cell cultures used for the production of monoclonal antibodies. The new cell density monitor will find applications in both research and production scale cell culture processes for producing monoclonal antibodies where the monitor will help increase the speed of process development and help optimize the process yields through improved process control.

Principal Investigator:

Ronald H. Micheels
7814492284
RON@POLESTARTECH.COM

Business Contact:

Karen Carpenter
7814492284
KCARPENTER@POLESTARTECH.COM
Small Business Information at Submission:

POLESTAR TECHNOLOGIES, INC.
POLESTAR TECHNOLOGIES, INC. 220 RESERVOIR ST, STE 32 NEEDHAM HEIGHTS, MA 02494

EIN/Tax ID: 043203282
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No