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Biomimetics for treating biofilm-embedded infections

Award Information

Department of Defense
Award ID:
Program Year/Program:
2009 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Army 09-004
Solicitation Number:
Small Business Information
PolyMedix, Inc.
170 N. Radnor-Chester Road RADNOR, PA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2009
Title: Biomimetics for treating biofilm-embedded infections
Agency / Branch: DOD / ARMY
Contract: W911NF-09-C-0093
Award Amount: $100,000.00


Multi-drug resistant (MDR) biofilms are perhaps the most difficult bacterial infections to fight. They require novel antibiotics that operate through new mechanisms which overcome the biofilm environment. We have discovered a class of antibiotics that are novel and have new targets which appear to evade resistance development. One example is already in the clinic to systemically treat Staphyloccal infections, including methicillin-resistant S. aureus. In addition, we have shown compounds in this series are active against bacterial and fungal biofilms. This STTR aims to identify a number of lead candidates with single micromolar activity against A. baumanni, S. epidermidis, E. faecalis, P. aeruginosa, E. coli and their drug/multi-drug resistance strains in Phase I. Active compounds that meet criteria for further evaluation (including those that have been shown previously to be active against drug-resistant S. aureus) will then be tested and optimized in Phase II to treat MDR biofilm infections.

Principal Investigator:

Richard W. Scott
VP Research, PolyMedix

Business Contact:

Dawn Eringis
Director, Scientific Affairs
Small Business Information at Submission:

PolyMedix, Inc.
170 N. Radnor-Chester Road Suite 300 Radnor, PA 19087

EIN/Tax ID: 270125925
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of Massachusetts, Amherst
Office of Grant and Contract A
70 Butterfield Terrace
Amherst, MA 1003 -9242
Contact: Carol Sprague
Contact Phone: (413) 545-0698
RI Type: Nonprofit college or university