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THIS RESEARCH IS INTENDED TO PROVIDE NEW SOLUBLE PLASTIC EMBEDDING RESINS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1494
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1494
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Polysciences Inc
400 Valley Road Warrington, PA 18976
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: THIS RESEARCH IS INTENDED TO PROVIDE NEW SOLUBLE PLASTIC EMBEDDING RESINS USEFUL IN PREPARING MORPHOLOGICALLY SUPERIOR TISSUE SECTIONS FOR ELECTRON AND LIGHT MICROSCOPY.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THIS RESEARCH IS INTENDED TO PROVIDE NEW SOLUBLE PLASTIC EMBEDDING RESINS USEFUL IN PREPARING MORPHOLOGICALLY SUPERIOR TISSUE SECTIONS FOR ELECTRON AND LIGHT MICROSCOPY. THESE POLYMERS WHICH ARE NOT CROSS-LINKED ARE AMENABLE TO A MILD SOLVENT TREATMENT WHICH ALLOWS PENETRATION BY IMMUNOGLOBULINS AND OTHER TISSUE MARKERS WHICH ARE OF GREAT CURRENT INTEREST. SUCH AN EMBEDDING RESIN WILL MINIMIZE THE PATIENT COST AND THE AMOUNT OF PATIENT BIOPSY TISSUE AND AT THE SAME TIME INCREASE THE DIAGNOSTIC VALUE FROM A SINGLE EMBEDDED BLOCK. OUR APPROACH PROPOSES THE DEVELOPMENT OF POLYMERS WHICH ARE E-BEAM STABLE AND CAPABLE OF BEING THIN SECTIONED THUS ALLOWING THE PHYSICAL PROPERTIES NECESSARY FOR ELECTRON MICROSCOPY AND LIGHT MICROSCOPY MICROTOMY. THIS WILL BE ACCOMPLISHED BY INCORPORATING INTO THE POLYMERIC COMPOSITIONS AROMATIC NUCLEI WHICH RENDER THE POLYMER ELECTRON BEAM STABLE. BY ADJUSTING COPOLYMER COMPOSITION: THE HARDNESS, SOLUBILITY, CHEMICAL AND STAINING CHARACTERISTICS OF THE POLYMER WILL BE MODIFIED TO YIELD THE DESIRED SECTIONING PROPERTIES. THE COMMERCIAL ACCEPTANCE OF EMBEDDING MEDIA WHICH MEETS THE CRITERIA WE HAVE PROPOSED IS VERY PROMISING AS RESEARCHERS AND CLINICAL LABORATORIES HAVE NEED OF SAME FOR THIN IMMUNODIAGNOSTIC TEST PROCEDURES.

Principal Investigator:

Jack radell
TECHNICAL DIRECTOR
0

Business Contact:

Small Business Information at Submission:

Polysciences Inc.
400 Valley Road Warrington, PA 18976

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No