DESCRIPTION (Adapted from applicant's abstract): Our understanding of the molecular control of neuronal function and synaptic transmission is limited because studies are performed using high resolution molecular genetic approaches within the limits of diffraction limited optical microscopy. To… More

DESCRIPTION (Adapted from applicant's abstract): Our understanding of the molecular control of neuronal function and synaptic transmission is limited because studies are performed using high resolution molecular genetic approaches within the limits of diffraction limited optical microscopy. To… More

DESCRIPTION (provided by applicant): Cellular studies of learning and memory, and synaptic transmission are significantly hampered by standard optical configurations that were developed decades ago. This is especially true when considering present day, fluorescence… More

DESCRIPTION (provided by applicant): Recent developments in near-field instrumentation have provided PRAIRIE TECHNOLOGIES with the necessary understanding to develop a multi-mode confocal microscope that will integrate confocal microscopy with simultaneous… More

DESCRIPTION (provided by applicant) Confocal microscopy is an essential tool for the biological sciences. It has significantly enhanced the testing of hypotheses in the Neurosciences and has provided insights into the causes of… More

Reading the conformational state of membrane proteins is central to understanding their role in cell signaling, to using them as sensor elements and for screening candidate drug compounds that are targeted toward this important class of biomolecules. While the patch clamp technique for doing this… More

DESCRIPTION (provided by applicant): Millions of people in the USA and throughout the world are affected by neurological disorders such as epilepsy, Parkinson's disease and brain tumors. Confocal microscopy has considerably enhanced the testing of hypotheses in the basic neurosciences, providing… More

DESCRIPTION (provided by applicant): Reading the conformational state of membrane proteins is central to understanding their role ir cell signaling, to using them as sensor elements and for screening candidate drug compounds that are targeted toward this important class of biomolecules. While the… More

DESCRIPTION (provided by applicant): Current two-photon (2P) confocal imaging systems are built around traditional confocal microscope scan heads that use galvanometers to control laser beam scanning. This technology significantly limits scanning speed. Building on recent developments of… More

DESCRIPTION (provided by applicant): A primary goal in neuroscience is to understand at a mechanistic level the functioning of neuronal networks with specific behaviors. This involves in general, the anatomical connectivity among the various types of neurons within the local network, the… More