THE SWEPT FIELD CONFOCAL MICROSCOPE
DESCRIPTION (provided by applicant)
Confocal microscopy is an essential tool for the biological sciences. It has
significantly enhanced the testing of hypotheses in the Neurosciences and has
provided insights into the causes of neurological disorders. The goal of this
project is to develop a new type of confocal microscope based on a new concept,
the swept-field confocal design (SFC). The SFC has the potential of becoming an
attachment for the light microscope that could be purchased by the individual
scientist for under $50,000. The SFC is a revolutionary confocal concept in
which this hybrid-instrument uses an 86 x 12 array of stationary pinholes for
illumination and detection along one axis (e.g. the Y axis) while using one
galvanometer to sweep the illumination along the X axis. This phase I project
has five specific objectives.
We will: 1) Design and build a swept-field confocal microscope; 2) modify
existing digital camera acquisition software to make SFC control software; 3)
Compare the optical efficiency and resolution of the SFC and present day LSCMs;
4) Calculate the manufacturing costs of the SFC and determine whether the SFC
could come to market at $45,000, and finally 5) Test the performance of the
swept-field confocal microscope in biological applications.
Small Business Information at Submission:
PRAIRIE TECHNOLOGIES, INC.
PRAIRIE TECHNOLOGIES, INC. 3230 DEMING WAY, STE 175 MIDDLETON, WI 53562
Number of Employees: