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Third World Diagnostics--A One-Step Immunoassay for TSH

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Princeton Biomeditech
4242 U.S., Route 1 Monmouth Junction, NJ 08852
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 1994
Title: Third World Diagnostics--A One-Step Immunoassay for TSH
Agency: HHS
Contract: 1 R43 HD31379-1,
Award Amount: $73,520.00


Our goal is to develop a self-performing, one-step, semi-quantitative, visual immunometric assayfor human TSH. This assay will use whole blood as a substrate and indicate whether serum levels ofTSH in excess of 5 IU/ml are present. It will contain a built-in control to indicate successful assaycompletion. This assay will be helpful as a screen for neonatal hypothyroidism, especially in populationsthat lack the technological infrastructure required to perform currently available TSH assays. It will alsobe used to screen samples in a cost-effective fashion for the presence of an elevated TSH and thusindicate whether a sample requires a more expensive quantitative TSH assay. By allowing TSHmeasurement to be performed outside of a laboratory and by providing a screening method o detect anelevation in TSH, this assay represents a significant technical innovation. Because of its low cost andease of use, it will have considerable commercial application as a replacement for more expensive andcumbersome radio-, enzyme-linked, fluorescent, and chemiluminescent immunoassays.

Principal Investigator:

Jemo Kang

Business Contact:

Small Business Information at Submission:

Princeton Biomeditech
4242 U.S., Route 1 Monmouth Junction, NJ 08852

Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No