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FELINE HERPESVIRUS-1 (FHV-1) IS A MAJOR PATHOGEN OF CATS WITH WORLDWIDE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2922
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2922
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Probe-tek
3010 South Washington Ave Lansing, MI 48910
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: FELINE HERPESVIRUS-1 (FHV-1) IS A MAJOR PATHOGEN OF CATS WITH WORLDWIDE DISTRIBUTION.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

FELINE HERPESVIRUS-1 (FHV-1) IS A MAJOR PATHOGEN OF CATS WITH WORLDWIDE DISTRIBUTION. COMMERCIALLY AVAILABLE LIVE VACCINES AGAINST FHV-1 ARE WIDELY USED BUT THEIR RECOGNIZED SERIOUS DRAWBACK IS THE LACK OF COMPLETE ATTENUATION OF THE VIRUS RESULTING IN THE OCCURRENCE OF VACCINE-INDUCED CLINICAL SIGNS. THE OVERALL OBJECTIVE OF THE PROPOSED RESEARCH IS TO DEVELOP A RECOMBINANT DNA VACCINE AGAINST FHV-1 THAT IS SAFER AND MORE IMMUNOGENIC THAN EXISTING PRODUCTS. DURING PHASE I A PANEL OF MONOCLONAL ANTIBODIES AGAINST THE SURFACE GLYCOPROTEINS OF FHV-1 WILL BE DEVELOPED AND SCREENED FOR ANTIGENIC SPECIFICITY AND VIRUS-NEUTRALIZING ABILITY. THESE MONOCLONAL ANTIBODIES ARE THE ESSENTIAL TOOLS FOR ISOLATION OF INDIVIDUAL GLYCOPROTEINS WITH AFFINITY COLUMNS, MAPPING OF THE GLYCOPROTEIN GENES, AND SCREENING OF EXPRESSION VECTOR PRODUCTS, THE MAJOR OBJECTIVES OF PHASE II. THE VALUE OF THIS SYSTEM AS A MODEL FOR HUMAN HERPESVIRUS VACCINE DEVELOPMENT COMES FROM THE FACT THAT IT ALLOWS DEFINITION OF GLYCOPROTEIN-INDUCED IMMUNITY IN THE NATURAL HOST OF THE DISEASE.

Principal Investigator:

J. f. williams
PRINCIPAL INVESTIGATOR
5173937737

Business Contact:

Small Business Information at Submission:

Probetek, Inc.
3010 S. Washington Lansing, MI 48910

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No