The long-term objective of this project is the development and characterization of effective clot-dissolving therapy and, in particular, the study of a conjugate between human urokinase and a monoclonal antibody specific for human fibrin. this complex would allow for enhanced plasminogen activation… More

Cellular components of the immune system, including cytotoxic t cells, macrophages, and natural killer cells, are capable of the direct destruction of a variety of targetcells including allogenic cells and virus-infected or malignant cells within the host individual. research on these cellular… More

Progesterone receptor is one of a group of steroid hormone receptors that has been shown to have important regulatory effects in mammary and other target tissues. the qualitative and quantitative determination of progesterone receptor is useful in the therapeutic management of breast cancer.… More

The long-term objective of this project is the development and characterization of conjugates between plasminogen activators (urokinase, tissue plasminogen activator, single chain urokinase) and monoclonal antibodies specific for human cardiac heavy chain myosin. this type of conjugate byselectively… More

Difunctional carbonyl compounds are toxic, mutagenic, and carcinogenic and are ubiquitous contaminants of the human environment. the simplest examples of such compounds are malondialdehyde, acrolein, and methyl glyoxal. malondialdehyde is a product of lipid peroxidation and prostaglandin… More

A major problem in the treatment of cataracts by extracapsular lens replacement is the subsequent loss of vision due to secondary cataract formation. up to 50 percent of these patients may develop secondary cataracts. the major cause of this problem is a regrowth of lens epithelial cells that cannot… More