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PHOTODYNAMIC THERAPY SYSTEM WITH SINGLET O2 DOSIMETRY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7165
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7165
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Quantronix Corpon
49 Wireless Blvd, Box 9014 Smithtown, NY 11787
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: PHOTODYNAMIC THERAPY SYSTEM WITH SINGLET O2 DOSIMETRY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A SYSTEM FOR PHOTODYNAMIC THERAPY (PDT) THAT PROVIDES, IN ADDITION TO THE THERAPEUTIC LIGHT DOSE, A METHOD OF REAL-TIME, INTRAOPERATIVE DOSIMETRY WILL BE ASSEMBLED AND DEMONSTRATED. IN PDT, A PARENTERALLY ADMINISTERED PHOTOACTIVE DYE (DIHEMATOPORPHYRIN ETHER, DHE) LOCALIZES IN MALIGNANT TISSUE. SUBSEQUENT IRRADIATION OF THE DHE-BEARINGTISSUE WITH LIGHT (630NM) PRODUCES, IN COMBINATION WITH OXYGEN, THE CYTOTOXIC REACTION PRODUCT, SINGLET OXYGEN ((1)O2). BY MONITORING THE REAL-TIME-RESOLVED (1)O2 FLUORESCENCE AT 1.27 NM, A SIGNAL PROPORTIONAL TO THE (1)O2 PRODUCTION RATE WILL RESULT, THEREBY PROVIDING DOSIMETRY INFORMATION. THE SYSTEM TO BE DEMONSTRATED EMPLOYS A CW-PUMPED, Q-SWITCHED, FREQUENCY-DOUBLED YAG LASER DRIVING A TUNABLE DYE LASER EMITTING 70-NANOSECOND, 630-NANOMETER WAVELENGTH PULSES AT A 10-KHZ RATE. IN ADDITION TO PROVIDING REAL-TIMEDOSIMETRY INFORMATION, THE SYSTEM ALSO ALLOWS FOR THE STUDY OF A POSSIBLE INCREASE IN THE THERAPEUTIC EFFECT DUE TO THE GENERATION OF THE CYTOTOXIC AGENT (1)O2 IN "BURSTS." TO DATE, THE RECIPROCITY OF THE PDT LIGHT DOSE DOES NOT APPEAR TO HAVE BEEN THOROUGHLY INVESTIGATED. FINALLY, THE INHERENT WAVELENGTH AGILITY OF A TUNABLE DYE LASER MAKES THIS SYSTEM USEFUL WITH NEW PHOTOACTIVE DYES OPERATING BEYOND 630 NM.

Principal Investigator:

Martin g cohen phd
5162736900

Business Contact:

Small Business Information at Submission:

Quantronix Corp
Po Box 9014 49 Wireless Blvd Smithtown, NY 11788

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No