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A Novel Microfludic Device for Drug Toxicity Studies

Award Information

Agency:
Department of Defense
Branch:
Office for Chemical and Biological Defense
Award ID:
96629
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
C101-103-0045
Solicitation Year:
N/A
Solicitation Topic Code:
CBD 10-103
Solicitation Number:
N/A
Small Business Information
CFD Research Corporation
701 McMillian Way NW, Suite D Suite D Huntsville, AL 35806-
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: A Novel Microfludic Device for Drug Toxicity Studies
Agency / Branch: DOD / CBD
Contract: HDTRA1-10-P-0039
Award Amount: $69,998.00
 

Abstract:

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitative prediction of the toxicity of the drug agent. This device while accelerating the drug screening development process will also reduce animal trials significantly. Our device accurately reproduces the physiological conditions (morphology, flow and cellular make-up) comprising of the respective cells from the targeted organ of interest. Phase I effort will focus on proof of concept studies using liver cells (hepatocytes) as model for toxicity analysis. In Phase II, the device will be extended to include cells from other targeted organs of interest. Animal experiments will be performed to validate the in vitro model. A high throughput device will be developed by integrating the developed prototype with microwell plates.

Principal Investigator:

Balabhaskar Prabhakarpandian
Principal Scientist
2563270665
tsb@cfdrc.com

Business Contact:

Deborah Phipps
Senior Contracts Specialist
2567264884
dap@cfdrc.com
Small Business Information at Submission:

CFD Research Corporation
215 Wynn Dr., 5th Floor Huntsville, AL 35805

EIN/Tax ID: 630944385
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No