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ANTIGEN PRODUCTION & TROUT IMMUNIZATION AGAINST INFECTIOUS HEMATOPOIETIC…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
2648
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
2648
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Rangen, Inc.
P.O. Box 706, 115 13th Ave. S. Buhl, ID 83316
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: ANTIGEN PRODUCTION & TROUT IMMUNIZATION AGAINST INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS
Agency: NSF
Contract: N/A
Award Amount: $180,000.00
 

Abstract:

IMMUNIZATION IS THE ONLY PRACTICAL CONTROL FOR HIGHLY DESTRUCTIVE INFECTIOUS HEMATOPOIETIC NECROSIS (IHN) VIRUS INFECTIONS OF TROUT AND SALMON. IHN VIRUS GROWN IN CELL CULTURE EITHER GIVES TOO LITTLE ANTIGEN OR THE MATERIAL IS NOT SUFFICIENTLY ANTIGENIC FOR USE AS A KILLED-VACCINE. BUTVIRUS REPLICATION AND SHEDDING DURING EPIZOOTICS PRODUCE HIGH LEVELS OF NATURAL INFECTIVITY AND, PERHAPS, A FORM HAVING GREATER IMMUNOGENICITY. OUR OBJECTIVES ARE TO HARVEST WATERBORNE INFECTIVITY, CONCENTRATE AND TREAT IT, AND TEST RESULTING PREPARATIONS FOR CONFERRING IMMUNITY. THE APPROACH IS TO INDUCE IHN EPIZOOTICS IN TROUT POPULATIONS, PASS EFFLUENTS THROUGH ADSORPTION MEDIA, DISSOCIATE CONCENTRATED MATERIAL , KILL OR MODIFY THE VIRUS,CONTACT TROUT POSTLARVAE WITH THE KILLED PREPARATIONS AS SUCCESSFULLY DONE WITH BACTERIN VACCINES, AND EVALUATE POTENTIAL IMMUNIZATION. IF REASONABLE PROTECTION IS CONFERRED, THE PROCESSES ARE TO BE OPTIMIZED AND USED FOR VACCINE COMMERCIALIZATION.

Principal Investigator:

Blake F Grant Phd
Director Iarc
2085436421

Business Contact:

Small Business Information at Submission:

Rangen Aquaculture Research
Route 1 Box 264 Hagerman, ID 83332

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No