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THE LONG TERM RESEARCH OBJECTIVE IS TO PRODUCE LIPOPHILIC PENICILLINS OR…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1365
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1365
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Recomtex Corpon
4700 South Hagadorn Road Suite 290 Lansing, MI 48823
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: THE LONG TERM RESEARCH OBJECTIVE IS TO PRODUCE LIPOPHILIC PENICILLINS OR CEPHALOSPORINS CAPABLE OF CROSSING THE BLOOD-BRAIN BARRIER.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG TERM RESEARCH OBJECTIVE IS TO PRODUCE LIPOPHILIC PENICILLINS OR CEPHALOSPORINS CAPABLE OF CROSSING THE BLOOD-BRAIN BARRIER. SUCH DRUGS WILL BE VALUABLE IN THE TREATMENT OF MENINGITIS, PARTICULARLY THOSE CAUSED BY H. INFLUENZA, N. MENINGIDITIS, OR CERTAIN GROUPS OF STREPTOCOCCI IN NEONATES. THEY WOULD CONSTITUTE A NEW CLASS OF ANTIBIOTIC AND ATTRACT THE IMMEDIATE ATTENTION OF SEVERAL ETHICAL PHARMACEUTICAL MANUFACTURERS. DURING PHASE II THE APPLICANT WOULD ENTER A DEVELOPMENT AGREEMENT WITH ONE SUCH CORPORATION. THE PHASE I OBJECTIVES ARE TO PREPARE ANALOGS OF PENICILLIN G IN WHICH ITS PHENYLACETATE MOIETY IS REPLACED BY 5-METHYL RESORCINOL, 5-PENTADECYL-RESORCINOL, 5-HENEICOSYLRESORCINOL, 6-N-HENEICOSYL-4-HYDROXY-PYRAN-2-ONE, AND 5-PENTADECYLPHENOL, COMPOUNDS WHICH RENDER MEMBRANES PERMEABLE TO CERTAIN IONS AND SMALL MOLECULES. IN ALL CASES, THE PHENOXYACETATE OF EACH OF THE ABOVE COMPOUNDS WILL BE SYNTHESIZED AND THESE THEN COUPLED TO 6-AMINO-PENICILLANIC ACID. THE ANTIBIOTIC POTENCY OF THE PENICILLIN ANALOGS WILL BE TESTED AGAINST BOTH LACTAMASE POSITIVE AND NEGATIVE STRAINS OF THE AGENTS CAUSING MENINGITIS. PRELIMINARY TOXICITY STUDIES WILL BE CONDUCTED IN MICE INJECTED WITH GRADED AMOUNTS OF THE LIPOPHILIC PENICILLINS. THE MOUSE BRAINS WILL BE EXTRACTED TO DETERMINE THE LEVELS OF "RESORCINOLIC" ANTIBIOTICS PRESENT RELATIVE TO CONTROL PENICILLINS OR CEPHALOSPORINS.

Principal Investigator:

Harold l. sadoff
RESEARCH DIRECTOR
0

Business Contact:

Small Business Information at Submission:

Recomtex Corpon
919 East Grand River Ave. East Lansing, MI 48823

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No