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ISOLATION OF FETAL CELLS FROM MATERNAL CIRCULATING BLOOD

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7206
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7206
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Recomtex Corpon
4700 South Hagadorn Road Suite 290 Lansing, MI 48823
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: ISOLATION OF FETAL CELLS FROM MATERNAL CIRCULATING BLOOD
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

AN INCREASING NUMBER OF WOMEN DELAY PREGNANCY IN FAVOR OF CAREERS. CURRENTLY, 20 PERCENT OF ALL LIVE BIRTHS IN THE UNITED STATES ARE TO WOMEN OVER 30 YEARS OF AGE. THE RISK OF AN ABNORMAL CHILD DUE TO CHROMOSOMAL DEFECTS INCREASES NONLINEARLY WITH AGE, 1 PER 385 BIRTHS FOR WOMEN AGE 30 AND 1 PER 81 BIRTHS AT AGE 39. THUS, IT IS UNDERSTANDABLE THAT WOMEN OF ADVANCING CHILD-BEARING AGE ARE HIGHLY INTERESTED IN FETAL CHROMOSOMAL ANALYSIS. THIS ANALYSIS, KARYOTYPING, IS CURRENTLY DONE ON TISSUE OR CELLS OBTAINED BY CHORIONIC VILLUS SAMPLING AT 10 WEEKS OR AMNIOCENTESIS AT 16 TO 18 WEEKS GESTATION. BOTH PROCEDURES ARE SURGICALLY INVASIVE AND THUS POSE SOME RISK TO THE FETUS. RECOMTEX CORPORATION PROPOSES THAT FETAL CELLS PRESENT IN MATERNAL CIRCULATING BLOOD EARLY IN PREGNANCY CAN BE UTILIZED FOR KARYOTYPING. SMALL BLOOD SAMPLES WERE TAKEN FROM THE VEIN IN THE ARM OF PREGNANT WOMEN AT 7 TO 12 WEEKS OF GESTATION DURING EACH PROPSECTIVE MOTHER'S FIRST VISIT TOHER OBSTETRICIAN. THE REMOVED RED AND WHITE BLOOD CELLS ANDFETAL CELLS WERE THEN ISOLATED USING APPROPRIATE IMMUNOLOGICAL PROCEDURES. HUMAN FETAL CELLS ARE BEING CULTURED IN PREPARATION FOR KARYOTYPING.

Principal Investigator:

Harold l sadoff phd
5173321600

Business Contact:

Small Business Information at Submission:

Recomtex Corpon
4700 South Hagadorn Road Suite 290 Lansing, MI 48823

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No