Several experimental anti-viral aids drugs (azt, ddc, dda) are based on chemically modified deoxynucleosides. these deoxynucleoside derivatives are made from ribonucleosides due to the unavailability of the deoxynucleosides at a reasonable cost. considering the need for anti-viral drugs and the… More

The goal of this project is to develop a therapeutic agent which would replace heparin. although heparin is the best drug for treatment of thromboembolic disease, it is unstable if administered orally and must therefore be administered by the intravenous or subcutaneous route. in addition, the… More

The major goal of this project is to produce antisense-oligodeoxynucleotides that will readily be taken up by target cells. to accomplish this, we will attach antibiotics to antisense-oligodeoxynucleotides utilizing novel technologies. the antibiotics to be employed are readily taken up by… More

TELEPHONE NUMBER: (314) 429-7700 AWARDEE NUMBER: 1 R43 CA61390-01 The overall objective is to develop polysulfated carbohydrate derivatives that will inhibit the action of fibroblast growth factors (FGF). FGF's have been implicated in several human cancers both as angiogenic factors and as growth… More

The overall objective is to develop a process to produce lactobionic acid that is free of oxidizing components. Lactobionic acid is an essential component of perfusion solutions used to preserve organs for transplantation (Sumimoto, 1990). It functions as an impermeant and calcium chelator as well… More

DESCRIPTION (provided by applicant): The overall objected is to develop an easy controlled method of delivery for anticancer nucleoside drugs [cytarabine (araC); cladribine] in their polymeric form as oligonucleotides. The monomer drugs, currently are delivered slowly through continuous infusion in… More

DESCRIPTION (provided by applicant): The goal of the project is to develop new positive inotropes, represented by specifically modified AMP molecules. All of the currently available positive inotropic agents have significant adverse effects with digitalis being the only orally available positive… More