USA flag logo/image

An Official Website of the United States Government

ISOLATION OF BULK DEOXYNUCLEOSIDES FOR AIDS DRUGS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7858
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
7858
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
RELIABLE BIOPHARMACEUTICAL CORPORATION
RELIABLE BIOPHARMACEUTICAL CORP. BOX 2517, 1945 WALTON RD ST. LOUIS, MO 63114
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: ISOLATION OF BULK DEOXYNUCLEOSIDES FOR AIDS DRUGS
Agency: HHS
Contract: N/A
Award Amount: $368,318.00
 

Abstract:

SEVERAL EXPERIMENTAL ANTI-VIRAL AIDS DRUGS (AZT, DDC, DDA) ARE BASED ON CHEMICALLY MODIFIED DEOXYNUCLEOSIDES. THESE DEOXYNUCLEOSIDE DERIVATIVES ARE MADE FROM RIBONUCLEOSIDES DUE TO THE UNAVAILABILITY OF THE DEOXYNUCLEOSIDES AT A REASONABLE COST. CONSIDERING THE NEED FOR ANTI-VIRAL DRUGS AND THE IMPORTANCE OF TIME AND COST, IT MAKES SENSE TO HAVE DEOXYNUCLEOSIDES AVAILABLE FOR DIRECT SYNTHESIS OF DEOXYNUCLEOSIDE DERIVATIVES. AN EXHAUSTIVE LITERATURE SEARCH INDICATES THAT A USSR PATENT (1983, S#SU1,004,403) ISTHE ONLY REFERENCE TO GUIDE US ON THE LARGE SCALE PRODUCTION OF THIS VALUABLE MATERIAL. A RESEARCH PROGRAM IS PROPOSED TO FULFILL THIS VOID AND TO ASSIST IN THE IMMEDIATE AVAILABILITY OF DEOXYNUCLEOSIDES. THE PROPOSED RESEARCH CONSISTS OF SEVERAL SEGMENTS; A) LARGE-SCALE PRODUCTION OF DNA FROM SALMON, B) ENZYMATIC HYDROLYSIS OF DNA TO MONONUCLEOSIDES FOLLOWED BY DEPHOSPHORYLATION TO A DEOXYNUCLEOSIDE MIXTURE, C) SEPARATION OF DEOXYNUCLEOSIDES WITHOUT INVOLVING SALTS, FOLLOWED BY CONCENTRATION OF THE MATERIAL AND D) QUALITY CONTROL FOR CROSS-CONTAMINATION OF ISOLATED DEOXYNUCLEOSIDES. IN EACH CASE, NOVEL APPROACHES WILL BE USED TO MINIMIZE THE PRODUCTION TIME AND COST OF THE FINAL PRODUCTS. THIS RESEARCH IS ALSO EXPECTED TO PRODUCE 5-METHYLDEOXYCYTIDINE AND 6-METHYLDEOXYADENOSINE WHICH ARE URGENTLY NEEDED TO STUDY THE MECHANISM OF GENE CONTROL AND EXPRESSION. A ROUGH ESTIMATE OF COST-ANALYSIS INDICATES UP TO 90 PERCENT PRICE REDUCTION OF DEOXYNUCLEOSIDES WITH THE SUCCESS OF THIS PROGRAM.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Reliable Chemical Co
1161 Research Blvd Saint Louis, MO 63188

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No