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LIGNINOLYTIC ENZYMES APPLIED TO KRAFT LIGNIN AND LIGNOSULFONATE UTILIZATION

Award Information

Agency:
Department of Energy
Branch:
N/A
Award ID:
2529
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
2529
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
REPLIGEN CORPORATION
REPLIGEN CORPORATION 41 SEYON ST, STE 100 WALTHAM, MA 02453
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: LIGNINOLYTIC ENZYMES APPLIED TO KRAFT LIGNIN AND LIGNOSULFONATE UTILIZATION
Agency: DOE
Contract: N/A
Award Amount: $479,000.00
 

Abstract:

LIGNIN, A COMPLEX ORGANIC POLYMER AND ONE OF THE EARTH'S MOST ABUNDANT MOLECULES, IS NOW A LOW-VALUE BY-PRODUCT OF WOOD PULP PROCESSING. THE MAJOR LIGNIN BY-PRODUCTS, KRAFT LIGNIN, AND LIGNOSULFONATES, COULD BE MORE USEFUL, HOWVERE, IF THEIR CHEMICAL STRUCTURE COULD BE SPECIFICALLY ALTERED. BY USING ENZYMES CAPABLE OF SPECIFICALLY DEGRADING AND MODIFYING LIGNIN, THESE BY-PRODUCTS WOULD FIND WIDER APPLICATIONS AS ADHESIVES, DISPERSANTS, AND FEEDSTOCK CHEMICALS. THESE LIGNIN DEGRADING AND MODIFYING (LDM) ENZYMES ARE PRODUCED UNDER SPECIFIED CULTURE CONDITIONS BY WHITE-ROT AND BROWN-ROT FUNGI AND BACTERIA. THE MAJOR ENZYMES PRODUCED BY THE WHITE-ROT FUNGUS PHANEROCHAETE CHRYSOSPORIUM HAVE BEEN PARTIALLY CHARACTERIZED. P. CHRYSOSPORIUM HAS BEEN SHOWN TO BE THE MOST POTENT LIGNINOLYTIC ORGANISM STUDIED. THIS PROGRAM IS TO FURTHER ISOLATE AND CHARACTERIZE LDM ENZYMES THAT CATALYZE SPECIFIC REACTIONS ON KRAFT LIGNIN AND LIGNOSULFONATES. THE REACTIONS IN- CLUDE A DEPOLYMERIZING ACTIVITY THAT CAN REDUCE THE SIZE OF THE LIGNIN SUBSTRATE AND A DECOLORIZING REAC- TION THAT ELIMINATES CHROMOPHORIC GROUPS FROM LIGNIN.

Principal Investigator:

Dr. Roberta Farrell
Principal Investigator
6188764333

Business Contact:

Small Business Information at Submission:

Repligen Corp.
101 Binney Street Cambridge, MA 02142

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No