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Company Information:

Company Name: Research Biochemicals,
City: Natick
State: MA
Zip+4: 01760
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,405,041.00 21
SBIR Phase II $3,265,061.00 8

Award List:

HIGH AFFINITY LIGANDS FOR SPECIFIC DOPAMINE RECEPTORS

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard A. Milius , Principal Investigator
Award Amount: $50,000.00

THE NATURE OF THE ADENOSINE RECEPTOR WILL BE STUDIED USING ADENOSINE AGONISTS AND ANTAGONISTS MODIFIED FOR SELECTIVITY AND POSSIBLE AFFINITY LABELING.

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: John l neumeyer , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
The nature of the adenosine receptor will be studied using adenosine agonists and antagonists modified for selectivity and possible affinity labeling. adenosine plays a key role in physiological processes, and currently no selective a1 ora2 antagonists have as yet been developed. selective agonists… More

HIGH AFFINITY LIGANDS FOR SPECIFIC DOPAMINE RECEPTORS

Award Year / Program / Phase: 1987 / SBIR / Phase II
Agency: HHS
Principal Investigator: Richard A. Milius , Principal Investigator
Award Amount: $264,000.00
Abstract:
The development of safer and more effective antipsychotic drugs requires the availability of sensitive probes of the dopamine (da) receptor, which is a site of action of these agents. research biochemicals proposes a program to prepare novel substances with selective agonist or antagonist action at… More

HIGH AFFINITY LIGANDS FOR THE COCAINE RECEPTOR

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

SYNTHESIS OF FLUORESCENT PROBES FOR MONITORING BRAIN RECEPTOR MOBILITY

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

SELECTIVE DOPAMINE D-1 AND D-2 FLUORESCENT PROBES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: NSF
Principal Investigator: Bakthavachalam B Phd
Award Amount: $50,000.00

SELECTIVE DOPAMINE D-1 AND D-2 FLUORESCENT PROBES

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: NSF
Principal Investigator: Bakthavachalam B Phd
Award Amount: $225,602.00
Abstract:
Dysfunction of dopamine systems in the brain have been implicated in endocrine, neurological and psychiatric disorders, and dopaminergic drugs are widely prescribed for these disorders. brain dopamine receptors are clearly implicated as the targets of these drugs. these receptors are in a mobile,… More

SYNTHESIS OF FLUORESCENT PROBES FOR MONITORING BRAIN RECEPTOR MOBILITY

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
Dysfunction of dopamine systems in the brain have been implicated in endocrine, neurological and psychiatric disorders, and dopaminergic drugs are widely prescribed for these disorders. brain dopamine receptors are clearly implicated as the targets of these drugs. these receptors are in a mobile,… More

BORON-CONTAINING ISOQUINOLINES AND BENZOIDIAZEPINES FOR TARGETING GLIOMA CELLS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr John L Neumeyer , Principal Investigator
Award Amount: $50,000.00
Abstract:
Boron neutron-capture therapy (bnct) is a binary system for delivering intensely ionizing radiation to tumors using a combination of boron-10 labeled molecules and thermal neutrons to achieve a tumorcidal effect. recent evidence has indicated that there are peripheral benzodiazepine- binding sites… More

AFFINITY LABELS FOR DOPAMINE RECEPTORS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $49,999.00

FLUORESCENT PROBES FOR BRAIN SEROTONIN RECEPTORS

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

HIGH AFFINITY LIGANDS FOR THE COCAINE RECEPTOR

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $404,247.00
Abstract:
A selective binding site for cocaine has been identified in brain membrane preparations from rodents, monkeys and humans. there is a high degree of correspondence between the relative potencies of various cocaine analogs in vivo and their binding affinity for the cocaine site in vitro. information… More

AFFINITY LABELS FOR DOPAMINE RECEPTORS

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $393,816.00
Abstract:
Dysfunction of brain dopamine (da) receptors has been implicated in endocrine, neurological, and psychiatric disorders. detailed pharmacological evaluation and the study of biochemical function of the da receptors have been made possible by the synthesis of high-affinity ligandsthat are selective… More

FLUORESCENT PROBES FOR BRAIN SEROTONIN RECEPTORS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $437,288.00
Abstract:
Dysfunction of serotoninergic (5ht) systems in the brain have been implicated in neurological and psychiatric conditions. drugs that interact with brain 5ht1a receptors are effective in relieving anxiety disorders. lsd and other hallucinogenic drugs have been shown to produce their psychoactive… More

PROBES OF THE IMIDAZOLINE/GUANIDINIUM RECEPTOR

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Neumeyer, John L , Principal Investigator
Award Amount: $50,000.00

BENZODIAZEPINE DERIVED CARBORANES FOR NEUTRON CAPTURE THERAPY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: John L Neumeyer
Award Amount: $50,000.00
Abstract:
Boron neutron-capture therapy (bnct) is a binary system for delivering intensely ionizing radiation to tumors using a combination of boron-10 labeled molecules and thermal neutrons in order to achieve a tumorcidal effect. recent evidence has indicated that there are peripheral type… More

PET AND SPECT IMAGING OF THE DOPAMINERGIC SYSTEM

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: John L Neumeyer
Award Amount: $50,000.00

PROBES OF THE IMIDAZOLINE/GUANIDINIUM RECEPTOR

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Neumeyer, John L , Principal Investigator
Award Amount: $500,000.00
Abstract:
The objective of this project is the synthesis and utilization of functionalized molecular probes specific for the imidazoline/guanidinium receptive site (igrs), a potential important receptor involved in metabolic and cardiovascular regulation. igrs-selective molecules will be chemically modified… More

Prodrugs of 5-FU¿Antitumor Agents for Breast Cancer

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Marianne R. Spada
Award Amount: $50,000.00
Abstract:
We will prepare novel prodrugs based upon 5F- uracil (FU) and to test their effectiveness against human breast normal mammary epithelial and tumor derived breast cells lines in culture. FU is one of the most used anticancer drugs. It has greater activity in combination with leucovorin. We will start… More

Simple Generator for Radiohalogenated Spect Agents

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard A. Milius
Award Amount: $80,093.00
Abstract:
A simple generator system to facilitate the production of SPECT agents is proposed. The radioligand to be used to demonstrate feasibility of this approach is beta-CIT (2beta-Carbomethoxy-3beta¿iodophenyltropane), a compound with high affinity for dopamine reuptake sites in human brain, which is… More

PET AND SPECT IMAGING OF THE DOPAMINERGIC SYSTEM

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: HHS
Principal Investigator: John L Neumeyer
Award Amount: $540,108.00
Abstract:
This application describes a collaborative program to develop non-invasive tools for the study of the molecular and biochemical mechanisms of central dopaminergic neurotransmission. the primary neurochemical abnormality in many dopamine (da) function-associated diseases appears tobe the alterations… More

Derivatives of uh 301 as Probes of the 5ht1a Receptor

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Yg Gao
Award Amount: $80,249.00
Abstract:
Phase I describes a collaborative program that will synthesize a series of compounds related to(S)-5-F-8-hydroxy-2-(dipropylamino)tetralin [(S)-UH-301], an antagonist of the serotonin 5HT1A receptor.Recently RBI has developed a procedure for the efficient synthesis of (S)-UH-301 that makes it… More

FLUORESCENT PROBES FOR THE D3 DOPAMINE RECEPTOR

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: NSF
Principal Investigator: V Bakthavachalam
Award Amount: $65,000.00
Abstract:
Fluorescent probes selective for the newly identified d-3 dopamine receptor (da) are being developed. since its discovery, the d-3 receptor has been recognized as a member of the d-2 like family of da receptors and is considered to be a possible site of action of antipsychotics. recently,… More

Pd-128,907 Based Dopamine D3 Receptor Fluorescent Probes

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: William White
Award Amount: $100,000.00
Abstract:
Fluorescently amended analogs of the autoreceptor selective agonist PD- 128,907 will be synthesizedfunctionalization through suitable spacer units at ring amended nitrogen followed by coupling with fHigh enantiomeric excesses for all targets will be achieved either by classical resolution or… More

Synthesis of Cyclic ADP Ribose

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: William White
Award Amount: $79,700.00
Abstract:
We will develop the total synthesis of cyclic adenosine diphosphate ribose (cADPR). We envision a csynthesis in which the morpholine- activated phosphoroamidate N,N'-dicyclohexylcarboxamidine salt of'phosphate is coupled to 2,3,5-tri-O-benzoyl-D-ribose. The protecting groups will be removed and… More

TC LABELED IMAGING AGENTS FOR THE DOPAMINE TRANSPORTERS

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

IMPROVED SYNTHESIS OF DRUGS OF ABUSE

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

FLUORESCENCE BINDING ASSAY FOR THE DOPAMINE RECEPTOR

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

PROBES FOR IMIDAZOLINE BINDING SITES

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00