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NEW CONCEPT FOR MICROSEQUENCING AT FEMTOMOLE LEVELS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11367
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11367
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Resift Inc
Iowa State University Park Ames, IA 50010
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: NEW CONCEPT FOR MICROSEQUENCING AT FEMTOMOLE LEVELS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE DETECTION AND SEQUENCING OF PEPTIDES BELOW THE 1-PICOMOLE LEVEL IS EXPECTED TO ESTABLISH NEW FIELDS OF RESEARCH IN THE BIOLOGICAL AND MEDICAL SCIENCES. RESIFT, INC., PLANS TO HELP OPEN THESE NEW FIELDS OF RESEARCH WITH AN INNOVATIVE INSTRUMENT THAT PROMISES FEMTOMOLE SENSITIVITY. THE INSTRUMENT IS SIMILAR TO A MASS SPECTROMETER BUT INSTRUMENTALLY IS MUCH SIMPLER. THIS RESEARCH WILL UTILIZE KNOWN NEUROPEPTIDES AND SPECIMENSFROM NEUROPHARMACOLOGICAL STUDIES TO DETERMINE THE OPTIMAL PARAMETERS FOR SAMPLE INTRODUCTION, MOLECULAR ION FORMATION, FRAGMENTATION, AND DETECTOR READOUT TO DETERMINE THE MOLECULAR WEIGHT AND AMINO ACID SEQUENCES OF THE NEUROPEPTIDES. THE STUDIES CONCERN THE DEMONSTRATION OF THE INSTRUMENT'S CAPABILITIES TO DETECT, IDENTIFY, AND SEQUENCE KNOWN PURIFIED PEPTIDES PRESENT IN NEURONAL TISSUE AND RELEASED AFTER ELECTRICAL STIMULATION OF RAT SENSORY FIBERS INTO THE PERFUSATE OF RAT SPINAL CORD SLICE PREPARATION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Resift Inc
Iowa State University Park Ames, IA 50010

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No