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Portable photonic sensor system as an early detection tool for ovarian cancer
- Small Business Information
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RESONANT SENSORS INC.416 Yates Street, Room NH518 Box 19016 ARLINGTON, TX 76010-1654View profile »Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2009Title: Portable photonic sensor system as an early detection tool for ovarian cancerAgency: HHSContract: 1R43CA135960-01A1Award Amount: $301,601.00
Abstract:
DESCRIPTION (provided by applicant): High-accuracy, portable sensor systems will be developed to provide near-instantaneous detection of biomarker proteins in blood and serum as indicators of ovarian serous papillary carcinoma to monitor presymptomatic asp ects of the disease, disease progression, and the efficacy of intervention therapies. These compact optical systems will be easy to use and have the capability to measure multiple agents simultaneously and in real time. The ultimate goal is to develop comm ercial systems capable of identifying and quantifying protein biomarkers that are either up- or downregulated in blood and serum associated with ovarian carcinoma. The present application will test the hypothesis that the proposed sensor systems are capabl e of providing near-instantaneous detection of biomarker proteins in blood and serum as indicators of ovarian carcinoma. The hypothesis will be tested with the following specific aims: Specific Aim 1: Develop a prototype sensor system and demonstrate its f easibility as a multi- channel portable biochemical detection system for biomarker proteins. A major additional goal will be to distinguish quantitatively between primary and metastatic ovarian carcinoma through differential protein quantification. Such in formation will be valuable for therapeutic decision making and the development of differential diagnostic and therapeutic strategies. Key milestones include: a) Design and specification of system components; b) Prototype assembly; and c) Test and performan ce verification. Specific Aim 2: Quantify sensor system performance, sensor overall functionality, and sensitivity for multi-protein detection in small volumes of blood and serum. Relevant biomarker protein concentrations will be measured using highly targ et-specific antibodies or aptamers and established laboratory model systems of ovarian serous papillary carcinoma. While sensor elements and systems have been fabricated in our labs previously, designs will be optimized for this application with tailored s urface chemistries to obtain a robust detection system for pre- clinical use. Results will be compared to those taken with standard methods to clearly quantify advantages of this new approach. Key milestones include: a) Quantitative sensor performance char acterization; and b) Sensor design and fabrication optimization using robust surface chemistries for research and pre-clinical use. PUBLIC HEALTH RELEVANCE: Among gynecologic tumors, ovarian carcinoma has the highest lethality rate with over 16,000 cases i n the US in 2005. Despite its high incidence rate, there are serious difficulties with diagnosis of the disease itself as well as with early detection of disease onset. In this project, powerful sensor systems will be developed that have the potential to p rovide early analysis and diagnosis thereby providing significantly refined therapeutic management and targeted therapy development for ovarian carcinomas.Small Business Information at Submission:RESONANT SENSORS INC.
416 Yates Street, Room NH518 Box 19016 ARLINGTON, TX 76010EIN/Tax ID: 562545305DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 93508 |
Program Year/Program: 2009 / SBIR |
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Agency Tracking Number: CA135960 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |