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IMPROVED TECHNETIUM-99M LABELING FOR CANCER IMAGING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11163
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
11163
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Rhomed, Inc.
C/O PALATIN TECHNOLOGIES, INC. Princeton, NJ 08540
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: IMPROVED TECHNETIUM-99M LABELING FOR CANCER IMAGING
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

A NEW METHOD OF DIRECT LABELING OF ANTIBODIES WITH TECHNETIUM-99M (TC-99M) WILL BE DEVELOPED AND EVALUATED. INTHIS METHOD, CALLED THE REGULATED REDUCTION METHOD, ONE CHEMICAL MEANS IS USED TO BREAK THE DISULFIDE BOND IN THE PROTEIN, AND A SEPARATE CHEMICAL MEANS IS USED TO REDUCE THE SODIUM PERTECHNETATE. USING THIS METHOD, TRANSCHELATION IS LOWER, AND HIGHER RADIOCHEMICAL PURITY RESULTS. THE METHOD WILL BE FORMULATED FOR A SIMPLE KIT FORMAT, ALLOWING QUICK LABELING WITH TC-99M WITH A MINIMUM OF STEPS. A NEW AND SIMPLE TC-99M LABELING METHOD WILL HAVE WIDE APPLICATION FOR DIAGNOSTIC IMAGING WITH MONOCLONAL ANTIBODIES. THE REGULATED REDUCTION METHOD WILL BE DEVELOPED USING TWO ANTIBODIES: B72.3, WHICH IS AN IGG, AND ANTI-SSEA-1, WHICH IS AN IGM. THE REGULATED REDUCTION METHOD WILL BE COMPARED TO THE PRETINNING DIRECT LABELING METHOD AND A BIFUNCTIONAL CHELATE METHOD, AND WILL BE TESTED FOR RADIOCHEMICAL PURITY, STABILITY, IMMUNOREACTIVITY, AND TRANSCHELATION.

Principal Investigator:


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Business Contact:

Small Business Information at Submission:

Rhomed Inc.
1020 Tijeras Ne Ste C Albuquerque, NM 87106

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No