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ACROSOME REACTION: DOT ASSAY TO DETECT MALE INFERTILITY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13757
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13757
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Rhomed, Inc.
C/O PALATIN TECHNOLOGIES, INC. Princeton, NJ 08540
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: ACROSOME REACTION: DOT ASSAY TO DETECT MALE INFERTILITY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A DOT IMMUNOASSAY FOR THE DETECTION OF ACROSOME REACTION OF HUMAN SPERM WILL BE DEVELOPED FOR USE IN THE DETECTION OF MALE INFERTILITY. SCREENING TESTS FOR THE DETERMINATION OF THE CAUSES OF INFERTILITY AND SCREENING SEMEN SAMPLES FOR SPERM BANKING HAVE BECOME MAJOR RESPONSIBILITIES OF FERTILITY CLINICS. HOWEVER, NO SIMPLE METHOD CURRENTLY EXISTS FOR THE DETERMINATION OF THE FUNCTIONAL ABILITY OF SPERM TO UNDERGO ACROSOME REACTION-A KEY STEP REQUIRED FOR PENETRATION OF OVUM BY SPERM. WHEN SPERM UNDERGO ACROSOME REACTION, AN ANTIGENIC DETERMINANT IS SHED THAT BINDS PEANUT AND PISUM SATIVUM AGGLUTININS OR MONOCLONAL ANTIBODIES REACTIVE WITH BETA-1,3-GAL-GALNAC. RESEARCH HAS SHOWN THAT THE RELEASE OFMARKERS CAN READILY BE DETECTED BY DOT IMMUNOASSAY USING EITHER LECTINS OR MONOCLONAL ANTIBODY BINDING. IN PHASE I OF THE STUDY, SEMEN SAMPLES WILL BE ANALYZED IN PARALLEL BY DOT IMMUNOASSAY AND FLUORESCENCE MICROSCOPY FOR ACROSOMAL REACTION. IN PHASE II, A DOT IMMUNOASSAY PRODUCT WILL BE DEFINED AND CLINICALLY TESTED TO ESTABLISH EFFICACY AS A SCREENING TEST FOR DETECTION OF SPERM THAT ARE UNABLE TO UNDERGO ACROSOME REACTION.

Principal Investigator:

Ari Ma'ayan
5057649977

Business Contact:

Small Business Information at Submission:

Rhomed Inc
1020 Tijeras Ne Albuquerque, NM 87106

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No