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The use of proteomics for surrogate markers of prion infection

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
76593
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
O052-H06-3030
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
RURAL TECHNOLOGIES, INC.
1008 32ND AVENUE BROOKINGS, SD 57006
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: The use of proteomics for surrogate markers of prion infection
Agency / Branch: DOD / OSD
Contract: W81XWH-06-C-0075
Award Amount: $99,991.00
 

Abstract:

Prion diseases are unique, in that their exceptionally long incubation period makes it difficult to diagnose prior to end-stage disease. While many diagnostic assays for infectious diseases rely upon detection of specific immunity, prion diseases apparently provoke no detectable immune response. Alternative tests must therefore be developed based upon concomitant changes in gene expression associated with disease progression. While a majority of pathogolical symptoms arise in the CNS, peripheral lymphoid tissues are an alternate site of prion proliferation. These peripehral lymphoid organs would be preferable sites for the analysis of protein expression differences associated with prion disease. The Canadian National Microbiology Laboratories have recently invested in a proteomics facility for the express purpose of analyzing transmissible spongiform encephalopathies. We have partnered with this facility, due to it's unique expertise and proximity to our facility in Brookings, South Dakota. Furthermore, we have arranged to acquire pathological blood and lymph samples from scrapie-infected sheep currently housed at South Dakota State University. Our researchers will then collect and analyze data obtained from these partnerships in order to target specific changes in protein expression associated with prion diseases.

Principal Investigator:

Christopher Mateo
Operations Manager
6056926953
cmateo@ruraltechinc.com

Business Contact:

Christopher Chase
President
6056926953
rtilab@brookings.net
Small Business Information at Submission:

RURAL TECHNOLOGIES, INC.
1008 32nd Ave Brookings, SD 57006

EIN/Tax ID: 460432479
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No