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Company Information:
Name:
RXBIO, INC.
Address:
1325 SUNSET DR
JOHNSON CITY, TN 37604-3619
JOHNSON CITY, TN 37604-3619
Located in HUBZone:
No
Woman-Owned:
No
Minority-Owned:
No
URL:
N/A
Phone:
N/A
Award Totals:
Award List:
LPA Receptor Modulators as Radioprotectants
Award Year / Program / Phase:
2007 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Veeresa Gududuru
Award Amount:
$97,162.00
Abstract:
DESCRIPTION (provided by applicant): The goal of this Phase I proposal is to perform lead optimization of a novel small molecular radioprotectant based on the Rx100 scaffold. Rx100, a metabolically stabilized analog of phospholipid growth factor lysophosph
atidic acid (LPA), has shown promising… More
Development of an LPA receptor modulator Rx100 as a radioprotectant
Award Year / Program / Phase:
2008 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Award Amount:
$99,977.00
Abstract:
DESCRIPTION (provided by applicant): Bone marrow and gastrointestinal mucosa are highly sensitive to radiation exposure. Radiation-induced damage to bone marrow and the gastrointestinal tract could be lethal in events such as nuclear accidents or radiation
terrorism, depending on radiation doses,… More
TAS::75 0849::TAS
Award Year / Program / Phase:
2011 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Wenlin Deng – 423-928-3330
Award Amount:
$194,797.00
Abstract:
No satisfactory medical interventions for radiation enteritis are available yet. We have demonstrated that polyamine inhibition by a-difluoromethylornithine orDFMO, a selective and irreversible inhibitor of ornithine decarboxylase (ODC, the primary rate-limiting enzyme in the production of… More