This Phase I proposal will test a UV-B light inducible system in tobacco to produce exceptionally large amounts of protein. There are three principal components to the system: 1) a tightly regulated, UV-B inducible promoter fused to a geminivirus replication associated protein (Rep) coding region,… More

DESCRIPTION (provided by applicant): Rxoa Biosciences, in collaboration with Arizona State University, is developing a novel maize-based production system for manufacturing pharmaceutical proteins. Transgenic maize seeds are employed as bioreactors to produce desired proteins to high intracellular… More

The objective of this proposal is to develop a rapid, simple, and efficient method to perform targeted homologous recombination in plants. We will produce a specialized vector that carries the desired mutant locus, then use controlled DNA replication to produce hundreds of circular DNA copies of… More

Rxoa Biosciences is developing a new technology known as Homologous Recombination (HR) which will give researchers the ability to precisely modify the genetic makeup of plants. Currently, this technique for modifying the genetic makeup of an organism has only been practical for bacterial, animal and… More

Rxoa Biosciences (Rxoa) proposes to develop a fast, reliable, cost-effective assay for Potato Virus Y (PVY). The $3 billion per year US potato industry requires a reliable and healthy seed potato supply. PVY is one of the top disease management issues for the over 2 billion pounds of seed potatoes… More