Narrow band, stable, single longitudinal mode continuously tunable solid state lasers are required for a number of applications such as lidars, high resolution spectroscopy, etc. it is proposed to develop a tunable, narrow band ( 0.001 cm(-1), stablle ( 0.0005 cm(-1) alexandrite laser by injection… More

This study will develop a prototype picosecond resolution time-resolved NIRS sensor forquantification of cerebral blood oxygenation and other clinicalapplications.

This project pertains to the development of a novel, cost effective,compact sensor for time resolved fluorescence spectroscopy of biological samples. the sensor has high-time resolution (sub-nanosecond) for accurate fluorescence decay time measurements with high sensitivity. the sensor is based on… More

This research contract will investigate the utility of Pseudo-Random Modulation (PRM) correlation tsignal processing as well as a proprietary Time Resolution Enhancement Technique to achieve up to 50using a moderate speed resolution and electronics. Our goal is the production of a low cost, time… More

Broadly tunable narrow band solid state lasers operating in the near infrared (0.7 to 1.1 m) are required for many scientific, medical and remote sensing applications. a new laser crystal, lisaf, offers a tremendous potential for the development of compact, efficient, tunable, near ir, diode-pumped… More

Not Available Active control of boundary layer separation using MAFC via periodic excitation has the potential of enabling aircraft with thick, separation-controlled wings with no moving control surfaces and thrust vectoring with no moving vanes or surfaces. The result will be significant… More

Not Available Recent studies indicate that there is a need for science and mathematics instruction, especially in 9th and 10th grade, which teaches students about current scientific issues and, provides them with problem-solving skills and technical expertise. Therefore, we will develop… More

Not Available APD proposes to investigate the feasibility of introducing its textile preforming processes for advanced composite materials manufacturing into the processing cycle for carbon phenolic heatshields, to address the need identified by the Navy Strategic Systems Program Office to identify… More

Not Available Expert Microsystems and Argonne National Laboratory (ANL) will develop an innovative state determination algorithm to improve the performance of our real-time sensor validation system. Automated detection of sensor failures provides an immediate return on

Not Available Many missions in x-ray astronomy require thin foil filters with enhanced strength and durability that provide high-throughput across the soft x-ray and extreme ultraviolet (EUV) spectrum. In particular, there are needs for soft x-ray filters with signific

We propose to develop an autonomous differential absorption lidar (DIAL) transmitter module for measurement of atmospheric ozone profiles from a high altitude unpiloted airborne vehicle (UAV). This UAV based lidar provides a powerful low cost capability for measurement of ozone distributions in the… More

We propose to build a rugged, low-cost fluorescence and aerosol lidar for detection and identification of bio-agent aerosols. By utilizing digital detection several orders of magnitude improvement in lidar performance is achieved, resulting in a muchsmaller lidar with superior range and sensitivity… More

We propose to build a rugged, low-cost fluorescence and aerosol lidar for detection and identification of bio-agent aerosols. By utilizing digital detection several orders of magnitude improvement in lidar performance is achieved, resulting in a muchsmaller lidar with superior range and sensitivity… More

We propose to develop a compact, robust differential absorption lidar (DIAL) for water vapor profiling from an unpiloted aeronautical vehicle (UAV) platform. The key to the innovation of this UAV DIAL is in a small, high performance, diode pumped Cr:LiSAF laser tunable in 830nm range. In a compact… More

We propose to develop a compact, robust differential absorption lidar (DIAL) for water vapor profiling from an unpiloted aeronautical vehicle (UAV) platform. The key to the innovation of this UAV DIAL is in a small, high performance, diode pumped Cr:LiSAF laser tunable in 830nm range. In a compact… More

We propose to develop a compact lidar for remote measurement and mapping of toxic chemicals (including the carcenogens benzene, benzo(a)pyrene, formaldehyde, TCDD, etc) released during the open-burn or detonation of hazardous propellents, munitions andpyrotechnics (PEP). The innovative two-component… More

DESCRIPTION (Verbatim from the Applicant's Abstract): Due to the strong water absorption bands in the about 3micro spectral region, 3-micro laser radiation is extremely appropriate for surgical intervention, especially where only shallow cutting beam penetration (incision… More

In Phase II we will develop a portable differential absorption lidar (DIAL) for remote measurement of toxic carcenogenic chemicals, such as, benzene, benzo(a)pyrene, formaldehyde, TCDD, released during the open-burn or detonation of hazardous propellents,munitions and pyrotechnics. The key component… More

An inexpensive aerosol lidar is proposed by combining inexpensive fiber coupled diode laser and photon counting detection technology for air quality monitoring in metropolitan area. The combination of inexpensive light source and high sensitivity photon detection technology developed in the "Micro… More

We propose to develop an autonomous differential absorption lidar (DIAL) transmitter module for measurement of atmospheric ozone profiles from a high altitude unpiloted airborne vehicle (UAV). This UAV based lidar provides a powerful low cost capability for measurement of ozone distributions in the… More

We propose to develop an autonomous differential absorption lidar (DIAL) transmitter module for measurement of atmospheric ozone profiles from a high altitude unpiloted airborne vehicle (UAV). This UAV based lidar provides a powerful low cost capability for measurement of ozone distributions in the… More

The main purpose of this proposal is to develop a novel interface for on- line coupling of liquid separation techniques to a mass spectrometer (MS) using an atmospheric pressure (AP) infrared (IR) matrix-assisted laser desorption/ionization (MALDI) method. In contrast to conventional MALDI where… More

The main purpose of this proposal is to develop a novel interface for on- line coupling of liquid separation techniques to a mass spectrometer (MS) using an atmospheric pressure (AP) infrared (IR) matrix-assisted laser desorption/ionization (MALDI) method. In contrast to conventional MALDI where… More

DESCRIPTION (provided by applicant): The main purpose of this proposal is to develop a novel ion source for biological mass spectrometry (MS). It will increase the ionization efficiency of biomolecules in the matrix-assisted laser desorption/ionization (MALDI) technique. Combined with a… More

We propose to develop a compact, high-average-power, high-repetition-rate, Q-switched diode-pumped Yb:YAG laser for applications such as target illumination from airborne and ground based mobile platforms. An innovative double TIR laser-head design willbe utilized to provide >150W of average power… More

DESCRIPTION (provided by applicant): The main goal of this proposal is to develop a novel method of fragmentation of biomolecules in an electrospray ionization (ESI) quadrupole/time-of-flight mass spectrometer (Q-TOF MS). The new method will enable many more bonds to cleave than a conventional… More

The purpose of this proposal is to develop a novel method of fragmentation of biomolecules in an electrospray ionization (ESI) quadrupole ion trap (QIT) mass spectrometer (MS) using an electron capture dissociation (ECD) technique. In experiments with polypeptide ions conducted in an ESI ion… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel tandem mass spectrometry (or MS/MS) technology for mass and structural analysis of biomolecules that could combine excellent ion isolation and fragmentation capabilities of a quadrupole ion trap (QIT) and high… More

We propose to develop high speed magnetostrictive and MEMS actuators for rapidly deflecting or deforming mirrors. High speed, light-weight, low voltage beam deflectors are required for rapid tuning of lasers, airborne and ground based lidar transmitters and receivers, image correctors, scanners,… More

DESCRIPTION (provided by applicant): The main purpose of this proposal is to develop a novel ion source for biological mass spectrometry (MS). It will increase the ionization efficiency of biomolecules in the matrix-assisted laser desorption/ionization (MALDI) technique by post-ionizing neutral… More

In Phase II we will develop a high brightness, high power, variable pulse repetition rate diode-pumped Yb:YAG laser suitable for military applications including target illumination from airborne or other mobile platforms. Utilizing an innovative near-grazing total internal reflection (TIR) resonator… More

The main goal of this proposal is to develop high speed magnetostrictive and MEMS actuators for rapidly deflecting or deforming mirrors. High speed, light-weight, beam deflectors are required for many NASA applications including rapid laser tuning, airborne lidar transmitters and receivers, image… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel instrument for mapping the distribution of targeted compounds in tissue sections with a spatial resolution of 20-40 um using atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI) mass… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel tandem mass spectrometry (or MS/MS) technology for mass and structural analysis of biomolecules that could combine excellent ion isolation and fragmentation capabilities of a quadrupole ion trap (QIT) and high… More

DESCRIPTION (provided by applicant): The primary objective of this proposal is the development of a new fragmentation technique to increase the information content of tandem MS experiments required for protein sequencing and identification. This will be achieved through the interaction of… More

DESCRIPTION (provided by applicant): Ion Mobility Spectrometer coupled with electrospray ion source and interfaced to a Mass Spectrometer is a powerful tool for the study of molecular conformations, separation of mass isomers, and analysis of complex mixtures and suppression of chemical background.… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to deliver a new efficient method of ion fragmentation, namely electron-transfer dissociation (ETD), to any mass spectrometer including low- cost bench top instruments such as triple and single quadrupoles. Although most of modern… More

DESCRIPTION (provided by applicant): This project is aimed at introducing a novel aspect to the Fourier transform ion cyclotron resonance mass spectrometry (FT ICR MS) to improve the mass range beyond those achieved with traditional FT ICR while retaining a high mass accuracy inherent to FT ICR MS… More

DESCRIPTION (provided by applicant): Although both electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) techniques have been interfaced with high resolution tandem mass spectrometers (MS) only MALDI tandem MS (or MS/MS) is currently suitable for high throughput… More

DESCRIPTION (provided by applicant): The primary objective of the proposed research is the development of a tandem orthogonal acceleration time-of-flight (TOF) mass spectrometer for high throughput proteomics applications with enhanced MS/MS capabilities. This will be achieved by building a dual… More

A novel method of using fluctuations in laser backscatter from atmospheric aerosol concentrations to remotely measure wind speed and direction is proposed. Using pulsed laser beams projected from a small spotting telescope and range gated detectors, we are able to remotely measure 2-D or 3-D wind… More

We propose to develop a small wind profiling lidar based on SESI and NASA technology that also produces boundary layer, cloud height, and cloud fraction data products. The wind measurements are based on the well established technique of aerosol structure time-lag correlation using a simple elastic… More

We propose to build a compact laser photoacoustic spectrometric (LPAS) sensor for continuous, real-time broadband analysis of multiple chemical components, and perform field tests to qualify it for dynamic monitoring of chemical warfare agents (CWA). Our sensor will be based on our laboratory LPAS… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel technology for high throughput mass analysis of biomolecules by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. FT-ICR mass spectrometers offer th e highest mass accuracy and resolution… More

DESCRIPTION (provided by applicant): It is vitally important to develop novel analytical tools and approaches for reliable identification and quantitation of protein posttranslational modifications (PTMs) such as phosphorylation. The existing approaches ar e mostly based on the combination of mass… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop a novel hybrid mass spectrometer with unique mass selection and fragmentation capabilities. Implementation of this instrument will advance methods of quantitation using isotopi cally labeled standards, multiple precursor… More

DESCRIPTION (provided by applicant): The main goal of this proposal is to develop a novel MS interface device, capable to provide an efficient ECD/ETD-type fragmentation of peptide and proteins at any mass spectrometer including low-cost bench-top instrume nts such as single- and triple-… More

We propose to build in Phase II a compact, rugged laser photoacoustic spectrometric (L-PAS) prototype sensor system (at technology readiness level TRL-6) for continuous, real-time broadband analysis of multiple chemicals. It will incorporate a tunable infrared quantum cascade laser (QCL),… More

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop novel hybrid ion mobility - FTICR instrument. Such combination using a novel ion mobility separation method is thought to extend the range of capabilities of the conventional F ourier transform ion cyclotron resonance… More

An elastic backscatter lidar operating at a covert wavelength in the ultraviolet can be employed to perform high-precision three-dimensional pointing and tracking of small UAV targes in a tactical environment. Imaging of the rapidly pulsing lidar beam will control the airspace by acquiring a hard… More

Science and Engineering Services. Inc. (SESI) proposes to develop an Aerosol Lidar Velocimeter (ALV) to obtain concurrent three-component wind velocity measurements in the downwash of a rotorcraft operating in shipboard environments. We propose to use a multi-beam lidar system to obtain aerosol… More

DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop a novel electrospray ion source operating inside the mass spectrometer, based on internal heating of small droplets and water clusters. The use of internal heating (c ontrary to external one by ambient gas) of… More

DESCRIPTION (provided by applicant): Ion mobility spectrometry (IMS) is a powerful analytical method having applications in the investigation of three dimensional structures and the structural changes that occur during chemical processes in compounds inclu ding clusters, synthetic polymers and… More

DESCRIPTION (provided by applicant): Modern proteomics tasks necessitate combining fast high-performance chromatographic separations with high-resolution mass spectrometers capable of recording tens of high- quality mass spectra per second. While retaining high mass accuracy of recorded spectra,… More

A novel method of using fluctuations in laser backscatter from atmospheric aerosol concentrations to remotely measure wind speed and direction is proposed. Using pulsed laser beams projected from two small spotting telescopes and range gated detectors, we are able to remotely measure 2-D wind… More