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ACCELERATOR PRODUCTION OF EPITHERMAL NEUTRONS FOR BNCT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11164
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
11164
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SCIENCE RESEARCH LABORATORY INC
15 Ward Street Somerville, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: ACCELERATOR PRODUCTION OF EPITHERMAL NEUTRONS FOR BNCT
Agency: HHS
Contract: N/A
Award Amount: $448,010.00
 

Abstract:

A NEW EPITHERMAL NEUTRON SOURCE WILL BE USED IN BORON NEUTRON CAPTURE THERAPY (BNCT). THE USE OF EPITHERMAL INSTEAD OF THERMAL NEUTRONS FOR BNCT IS ADVANTAGEOUS DUE TO THE GREATER PENTRATION DEPTH OF EPITHERMAL NEUTRONS IN TISSUE, WHICH SPARES SKIN DURING TUMOR IRRADIATION. EPITHERMAL NEUTRONS ARE PRODUCED BY BOMBARDING A LITHIUM TARGET WITH AN INTENSE PROTON BEAM FROM A CASCADE TANDEM ACCELERATOR (CTA). THE CTA IS A NOVEL ELECTROSTATIC ACCELERATOR THAT COMBINES TWO EXISTING TECHNOLOGIES INTO A SIMPLE, COMPACT PROTON ACCELERATOR SUITABLE FOR OPERATION IN A HOSPITAL ENVIRONMENT. PRELIMINARY CALCULATIONS INDICATE THAT A 1-MA, 2- TO 2.5-MEV PROTON BEAM INCIDENT ON THE TARGET WILL PROVIDE SUFFICIENT EPITHERMAL NEUTRON FLUX FOR BIOLOGICAL STUDIES AND FOR TUMOR IRRADIATION. IN THIS STUDY, TARGET AND NEUTRON MODERATOR GEOMETRY WILL BE MODELED USING MONTE CARLO TECHNIQUES TO DETERMINE THE OPTIMUM TARGET ASSEMBLY DESIGN AND PROTON BEAM PARAMETERS. THIS SYSTEM WILL BE CAPABLE OF PROVIDING A WIDE RANGE OF NEUTRON ENERGY SPECTRA, INTENSITIES, AND IRRADIATION TIMES FOR BOTH LABORATORY AND CLINICAL BNCT STUDIES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Science Research Laboratory
15 Ward St Somerville, MA 02143

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No