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Automated, Remote Production and Delivery of 15/O Radio

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22458
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22458
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SCIENCE RESEARCH LABORATORY INC
15 Ward Street Somerville, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Automated, Remote Production and Delivery of 15/O Radio
Agency: HHS
Contract: N/A
Award Amount: $49,998.00
 

Abstract:

Positron emission tomography (PET) with oxygen-15-labeled radiopharmaceuticals is becoming increasingly important in the study of mental illness. The synthesis and delivery of 15O-labeled compounds poses a unique challenged due to the extremely short half-life of this isotope and the requirement for multiple sequential doses in many procedures. This project will address the need for safe, convenient automated 15O-labeled radiopharmaceutical synthesis and patient administration. In Phase I, the key system components and automation required for production of 15O-labeled O2, CO, H2O, and butanol will be developed. Three innovative technologies will make possible a higher degree of system compactness and automation than previously achieved: an efficient, rapidly heated charcoal furnace, an in-line positron-sensitive radioactivity monitor, and a sensor for monitoring filter integrity in the final dose filtration step. The system will be housed in a self-shielded bedside unit and will allow automated, unassisted patient infusion of the liquid radiochemicals, thus, greatly reducing radiation dose to administering personnel. A simple user interface which can be controlled by the PET scanner operator will allow optimal scheduling of dose production and delivery. Phase I will culminate in the design of a system to be fabricated and tested in Phase II.

Principal Investigator:

Ruth E. Shefer
6175471122

Business Contact:

Small Business Information at Submission:

Science Research Laboratory
15 Ward Street Somerville, MA 02143

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No