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PRODUCTION OF CARBON-11-LABELED COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY WITH…

Award Information

Agency:
Department of Energy
Branch:
N/A
Award ID:
27261
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
27261
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SCIENCE RESEARCH LABORATORY INC
15 Ward Street Somerville, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: PRODUCTION OF CARBON-11-LABELED COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY WITH A LOW ENERGY ACCELERATOR
Agency: DOE
Contract: N/A
Award Amount: $74,981.00
 

Abstract:

A NEW GENERATION OF ECONOMICAL, COMPACT LOW ENERGY ACCELERATORS HAVE RECENTLY BECOME AVAILABLE FOR THE PRODUCTION OF RADIOISTOTOPES FOR POSITRON EMISSION TOMOGRAPHY (PET). THIS PROJECT ADDRESSES THE NEED FOR A CARBON-11 ((11)C) PRODUCTION TARGET AND RADIOCHEMICAL SYNTHESIS SYSTEM FOR USE WITH THESE NEW ACCELERATORS. (11)C-LABELED BIOLOGICAL MOLECULES ARE USED IN A WIDE VARIETY OF IMPORTANT PET APPLICATIONS, INCLUDING THE STUDY OF RECEPTOR-BASED SYSTEMS IN THE BRAIN AND HEART, OXIDATIVE METABOLISM IN TISSUE, AND GLUCOSE METABOLISM. (11)C TARGETS CURRENTLY USED WITH PET CYCLOTRONS ARE NOT SUITABLE FOR USE AT LOW BOMBARDING ENERGY. IN PHASE I, A NEW TECHNIQUE FOR THE PRODUCTION OF (11)C IN A SOLID TARGET VIA THE (11)B(P,N)(11)C NUCLEAR REACTION WILL BE INVESTIGATED. THE GOAL OF PHASE I WILL BE TO DEVELOP AN AUTOMATED TARGET DESIGN THAT PROVIDES (11)CO2 IN CLINICALLY USEFUL QUANTITIES, WITH HIGH RADIOCHEMICAL PURITY, AND WITH SUFFICIENTLY HIGH SPECIFIC ACTIVITY FOR THE LABELING OF RECEPTOR LIGANDS AS WELL AS ACETATE AND GLUCOSE. IN PHASE II, WE WILL COUPLE THIS TARGET TO AUTOMATED RADIOCHEMISTRY SYSTEMS FOR CONVERSION OF THE EXTRACTED ACTIVITY TO (11)C-RADIOPHARMACEUTICALS COMMONLY USED IN RESEARCH AND CLINICAL PET STUDIES.

Principal Investigator:

Dr Ruth E Shefer
6175471122

Business Contact:

Small Business Information at Submission:

Science Research Laboratory
15 Ward St Somerville, MA 02143

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No