DESCRIPTION (provided by applicant): The goal of this research project is to develop a new technology for microarray analysis that has superior performance and is more affordable than the currently available fluorescence-based microarrays. In Phase-I we have provided proof-of-principle for the… More

DESCRIPTION (provided by applicant): The goal of this research project is to develop a new technology for microarray analysis that has superior performance and is more affordable than the currently available fluorescence-based microarrays. In Phase-I we have provided proof-of-principle for the… More

This Small Business Innovation Research (SBIR) Phase I project is to establish the feasibility of a novel micro-array technology based on measurements of kinetics of hybridization of biopolymer molecules. By measuring kinetics of hybridization in real time, the perfectly and non-perfectly… More

In this project, we propose a new detection technology for identification of oligonucleotides, which works by detecting a bio-electronic response from hybridized duplexes. Compared with the conventional approach of using dye tagged oligos, the proposed electrochemical detector has significant… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new microarray system for performing gene expression analysis directly with total RNA without labeling and reverse transcription to cDNA. Achieving this goal will provide a critical breakthrough and establish a new… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new highly sensitive and cost effective Reverse Transcription Quantitative Bioluminescence Assay (RT-qBLA) for high-throughput detection and quantification of large (mRNA) and small (microRNA) RNAs in diverse biological… More

Real-time, in situ measurement and monitoring tools for interrogating biogeochemical processes in the subsurface environment are critical to assessing remediation performance and site stewardship at many contaminated DOE sites. In particular, in situ quantification and speciation analysis of… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new, highly sensitive, and cost-effective RNA Enzymatic Luminescence Assay (qELA) for high-throughput detection and quantification of microRNA in biological samples. The a ssay implements the same detection concept… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new microarray platform for performing high-multiplexed analysis of RNA and DNA without chemical modification of target molecules for detection. The main innovation of the propos ed approach is the use nanometer-size… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new highly sensitive and cost effective RNA Bioluminescent Assay (RT-qBLA) for high-throughput detection and quantification of RNA and DNA in biological samples. The assay imple ments the same detection concept known from… More

DESCRIPTION (provided by applicant): The goal of this SBIR project is to develop a new drug discovery platform for screening tyrosine kinase inhibitors. The main innovation of the proposed platform is the use of a multi-enzyme assay, which is able to measu re efficiency and identify inhibition… More

DESCRIPTION (provided by applicant): The goal of this SBIR Phase I project is the development of a new drug discovery platform for screening new inhibitors of viral polymerases and for studying mechanisms of action of the prospective pharmaceutical compoun ds. The main innovation in this project is… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a new highly sensitive and cost effective RNA Enzymatic Luminescence Assay (qELA) for high-throughput detection and quantification of microRNA in biological samples. The assay impl ements the same detection concept known… More