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MAGNETICALLY READABLE MICROARRAY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65274
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA084804
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SCI-TEC, INC.
10425 COGDILL RD. #300 KNOXVILLE, TN -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: MAGNETICALLY READABLE MICROARRAY
Agency: HHS
Contract: 2R44CA084804-03
Award Amount: $0.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of this research project is to develop a new technology for microarray analysis that has superior performance and is more affordable than the currently available fluorescence-based microarrays. In Phase-I we have provided proof-of-principle for the proposed approach of reading a DNA microarray produced directly on the surface of a computer diskette. With this approach, a modified disk drive of a personal computer can be used as a reader device. Potential applications of this new technology can include: (1) Creating new diagnostic classifications based on gene expression; (2) Discovery of signaling pathways and new targets of therapy; (3) Developing new markers of diseases; (4) Monitoring of treatment response and selection of the most appropriate therapy. During Phase II, we will produce a commercial prototype of the Magnetic Array System and, after careful evaluation and validation in Phase-II, we will make this system available for commercial production in Phase III. The objectives in Phase II will be achieved through the specific aims established as following: (1) The Magnetic Array System will be optimized by upgrading Array Reader Electronics; by developing a methodology for automated data filtering and quantitative characterization of the quality of the microarray data; and by introducing 3D-linker technology for producing high-performance microarrays in a format compatible with the magnetic array reader. (2) Microarray processing protocols will be finalized and a pilot production of the focused microarrays will be established for applications in cancer research. (3) The performance of the prototype of the Magnetic Array System will be evaluated through collaboration with research groups in academic institutions. For successful completion of Phase-II, Sci-Tec Inc. has established collaboration with academic institutions and businesses including the Material Analysis Center at Oak Ridge National Laboratory, the Medical Center of the University of Tennessee, the E.O. Lawrence Berkeley National Laboratory, Link Instruments (Fairfield, NJ), Zylux (Oak Ridge, TN), and Southeast Community Capital, a venture capital company organized to help and assist new technology businesses.

Principal Investigator:

Val V. Golovlev
8656712166
GOLOVLEV@AOL.COM

Business Contact:

Sl Chen
8656712166
SLCHEN@SCIEN-TEC.COM
Small Business Information at Submission:

SCI-TEC, INC.
SCI-TEC, INC. 10425 COGDILL RD, #300 KNOXVILLE, TN 37932

EIN/Tax ID: 621584121
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No