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CLOTTING FACTORS FROM FISH BLOOD FOR FIBRIN SEALANTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
39246
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
39246
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SEA RUN HOLDINGS, INC.
SEA RUN HOLDINGS, INC. 76 PINE ST FREEPORT, ME 04032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1997
Title: CLOTTING FACTORS FROM FISH BLOOD FOR FIBRIN SEALANTS
Agency: HHS
Contract: HL59032-01
Award Amount: $97,788.00
 

Abstract:

The overall objective of this project is to develop a medical fibrin sealant from fish plasma. Commercial aquaculture rears millions of large salmonids, and the plasma from these fish offers an unexplored and innovative source of highly conserved clotting factors. A major advantage is safety from mammalian infectious agents due to the remote phylogeny of fishes and differences in body temperature. Specific aims are to maximize fibrinogen and thrombin content of fish plasma, develop practical methods for harvest and extraction of these substances, characterize fish plasma clotting factors and a fish fibrin sealant in vitro, and conduct initial tests of this sealant in rats. Plasma fibrinogen and thrombin will be tested and compared in trout (Oncorhynchus mykiss) and salmon (Salmo salar) at different reproductive stages and under different environmental conditions, and optimum harvest conditions determined. Clot and sealant characteristics will be determined in vitro by rheologic testing and by incubation in human plasmin, and in vivo by comparing strength of rat skin incisions treated with fish fibrin sealant and a commercial sealant.

Principal Investigator:

Sawyer, evelyn s
0

Business Contact:


2079857957
Small Business Information at Submission:

Sea Run Holdings, Inc.
339 RIVER RD Arundel, MD 04046

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No