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Salmon clotting proteins for human bandages

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
45250
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
44341
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SEA RUN HOLDINGS, INC.
SEA RUN HOLDINGS, INC. 76 PINE ST FREEPORT, ME 04032
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: Salmon clotting proteins for human bandages
Agency / Branch: DOD / ARMY
Contract: DAMD17-02-C-0110
Award Amount: $99,900.00
 

Abstract:

Not Available "Fibrin bandages have shown considerable promise in controlling majorblood loss. However, two significant problems are cost, and thepossibility of infectious agents.Our overall objective is to solve both problems with the use offibrinogen and thrombin from salmon plasma. Phase I aims are: 1. Toprepare a viral-inactivated, stable, salmon fibrinogen and thrombin; and2. To characterize this material.Salmon clotting proteins are compatible with human proteins, and areless likely to be expensive due to the large untapped blood supply fromfarmed salmon. They offer safety from mammalian infectious agents,especially prions, due to the evolutionary distance between fish andmammals, and the low body temperature of these fish.We propose to develop viral-inactivation methods by spiking the salmonproteins with salmon viruses, and then determining virus titer afterlyophilization and heating. The virus-inactivated proteins will be usedfor stability studies that measure identity, purity, and potency, withand without additives, after defined storage conditions.Characterization studies of the salmon proteins will determine possibleadvantages over mammalian proteins.Salmon clotting proteins offer an effective, innovative, material forhuman use that is likely to be safer and less costly than humanproteins. The anticipated benefits of the proposed work is a safer, less -costlyfibrin bandage."

Principal Investigator:

Evelyn S. Sawyer
Director of Research
2079857957
esawyer@searunholdings.com

Business Contact:

Charleton H. Ames
Director
2077756000
hpasquine@mpn.ins.com
Small Business Information at Submission:

Sea Run Holdings, Inc.
339 River Rd. Arundel, ME 04046

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No