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Salmon clotting proteins for human bandages

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
63209
Program Year/Program:
2003 / STTR
Agency Tracking Number:
A2-0816
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SEA RUN HOLDINGS, INC.
SEA RUN HOLDINGS, INC. 76 PINE ST FREEPORT, ME 04032
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2003
Title: Salmon clotting proteins for human bandages
Agency / Branch: DOD / ARMY
Contract: DAMD1702C0110
Award Amount: $500,000.00
 

Abstract:

Fibrin bandages have shown considerable promise in controlling traumatic bleeding. However, two significant problems are cost, and the possibility of infectious agents.Our overall objective is to solve both problems with the use of fibrinogen and thrombin from salmon plasma. Phase II aim are to 1. Develop a formulation that is stable without refrigeration. 2. Demonstrate the level of immunogenicity. 3. Determine thechemical and functional equivalence of human and salmon fibrinogen and thrombin. 4. Prepare a prototype bandage for animal trials.Salmon clotting proteins are compatible with human proteins, and are likely to be less expensive due to the large untapped blood supply from farmed fish. Evolutionary distance and the low body temperature of the salmon point to safety from mammalianinfectious agents.We will follow FDA guidelines for further stability and viral inactivation work that will lead to a clinical formulation of the proteins. These formulations will be used for immunogenicity and toxicology studies, and applied to a prototype bandage.Salmon clotting proteins offer an effective, innovative material for human use that is likely to be safer and less costly than human material. The anticipated benefits ofthe proposed work are a safer and less costly bandage for human use

Principal Investigator:

Evelyn F. Sawyer
Director of Research
2078659655
esawyer@searunholdings.com

Business Contact:

Charlton H. Ames
Chairman
2077722054
zand2@msn.com
Small Business Information at Submission:

Sea Run Holdings, Inc.
76 Pine St. Freeport, ME 04032

EIN/Tax ID: 010449243
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIV. OF PENNSYLVANIA
221 Franklin Bldg, 3451 Walnut St.
Philadelphia, PA 19104
Contact: Andrew Rudczynski, Ph.D.
Contact Phone: (295) 898-7293
RI Type: Nonprofit college or university