USA flag logo/image

An Official Website of the United States Government

Salmon fibrin gels for surgical applications

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71769
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
NS048734
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SEA RUN HOLDINGS, INC.
SEA RUN HOLDINGS, INC. 76 PINE ST FREEPORT, ME 04032
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2006
Title: Salmon fibrin gels for surgical applications
Agency: HHS
Contract: 2R44NS048734-02
Award Amount: $755,175.00
 

Abstract:

DESCRIPTION (provided by applicant): Our objective is to develop a new biomaterial, a salmon-derived fibrin gel, which will bridge injured CMS tissue, support and promote axonal sprouting and growth, and deliver neurotrophic factors and cells. In Aim #1 we will test the efficacy of salmon-derived fibrin gels in animal models of CMS injury. Using the rat dorsal hemi-section, contusion, and fluid percussion models, we will compare the salmon material to human-derived fibrin gels for efficacy, inflammatory response, and possible functional changes. In Aim #2 we will seek to identify the growth-promoting factors that are involved in the salmon gels. We will determine if there is a small active molecule bound to the fibrinogen, and what properties of the fibrinogen molecule are important. In Aim #3 we plan pre-clinical studies of viral clearance, immunogenicity, and stability that are necessary for FDA approval of salmon fibrinogen and thrombin. We will spike the proteins with virus, and determine combinations of heat and gamma radiation that will achieve viral reduction, preserve protein efficacy, and not result in immunogenicity. Tissues from treated rats (Aim #1) will be examined for inflammatory response, and plasma samples taken for antibody studies. The cost of spinal cord and brain injury in both dollars and human suffering is a major public health issue. If the neurosurgeon could intervene with a material that promotes neuronal regrowth and connectivity, the impacts for the patient and for society are enormous.

Principal Investigator:

Evelyn S. Sawyer
2078659655
ESAWYER@SEARUNHOLDINGS.COM

Business Contact:

Charlton Ames
2078659655
zand@msn.com
Small Business Information at Submission:

SEA RUN HOLDINGS, INC.
SEA RUN HOLDINGS, INC. 76 PINE ST FREEPORT, ME 04032

EIN/Tax ID: 010449243
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No