USA flag logo/image

An Official Website of the United States Government

HUMAN PARAINFLUENZA TYPE 2 VIRUS GLYCOPROTEIN GENES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11415
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
11415
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Secretech, Inc.
1025 18th Street South Birmingham, AL 35205
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: HUMAN PARAINFLUENZA TYPE 2 VIRUS GLYCOPROTEIN GENES
Agency: HHS
Contract: N/A
Award Amount: $499,576.00
 

Abstract:

IT IS PLANNED TO CONSTRUCT A CDNA LIBRARY OF HUMAN PARAINFLUENZA TYPE 2 VIRUS MRNA'S INTO A PLASMID VECTOR. THE LIBRARY WILL BE SCREENED BY COLONY HYBRIDIZATION. THE GENES ENCODING ENVELOPE GLYCOPROTEINS WILL BE IDENTIFIED USING SPECIFIC PROBES IN SOUTHERN BLOT ANALYSIS, TRANSLATIONOF MRNA'S, AND SEQUENCE ANALYSIS. ONCE FULL-LENGTH CLONES ARE OBTAINED, THE CLONED GENES WILL BE USED FOR PRODUCTION OF THE RECOMBINANT GLYCOPROTEINS IN ABACULOVIRUS EXPRESSION SYSTEM, AND THE EXPRESSED GLYCOPROTEINS WILL BE EVALUATED TO DETERMINE THEIR IMMUNOGENICITY. THE LONG-TERM OBJECTIVE IS TO UTILIZE THESEGLYCOPROTEINS AS COMPONENTS OF A MULTIVALENT SUBUNIT VACCINE TO CONTROL PARAINFLUENZA VIRUS INFECTION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Secretech Inc.
1025 18th St S Suite 201 Birmingham, AL 35205

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No