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EVALUATION OF A MICROENCAPSULATED PARAINFLUENZA VACCINE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13646
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13646
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Secretech, Inc.
1025 18th Street South Birmingham, AL 35205
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: EVALUATION OF A MICROENCAPSULATED PARAINFLUENZA VACCINE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL TRIVALENT GLYCOPROTEIN SUBUNIT VACCINE FOR PARAINFLUENZA VIRUSES. BECAUSE OF THE HIGH COST OF PREPARING THESE GLYCOPROTEINS, A MEANS FOR ACHIEVING AN ENHANCED IMMUNE RESPONSE IS AN IMPORTANT OBJECTIVE AND IS THE FOCUS OF THIS RESEARCH. BIOCOMPATIBLE AND BIODEGRADABLE MICROSPHERES CONSISTING OF ACOPOLYMER OF DL-LACTIDE AND GLYCOLIDE (POLY DL-LACTIDE-CO-GLYCOLIDE) WILL BE UTILIZED TO INCORPORATE INACTIVATED HUMAN PARAINFLUENZA TYPE 3 (PI3) VIRUS ANTIGENS INTO SMALL SPHERICAL PARTICLES (1-10 MU M). MICROSPHERES CONTAINING VIRAL ANTIGENS WILL BE USED FOR SUBCUTANEOUS, INTRANASAL, AND ORAL IMMUNIZATION OF EXPERIMENTAL ANIMALS, AND THEIR IMMUNE RESPONSE WILL BE EVALUATED. A DIFFERENT GROUP OF ANIMALS WILL BE SIMILARLY IMMUNIZED WITH INACTIVATED VIRUS IN SOLUTION FOR COMPARISON. IF A SIGNIFICANT ENHANCEMENT IN THE PROTECTIVE IMMUNE RESPONSE IS OBSERVED USING MICROENCAPSULATED PI3 VIRUS ANTIGENS, MORE DETAILED STUDIES WILL BE SUBSEQUENTLY PURSUED FOR DEVELOPMENT OF A MULTIVALENT SUBUNIT VACCINE USING PARAINFLUENZA TYPE 1, 2, AND 3 ENVELOPE GLYCOPROTEINS. STUDIES WILL ALSO BE CONDUCTED TO UNDERSTANDTHE MECHANISM OF PROTECTION AND THE DURATION OF SUCH RESPONSE. FINALLY, MICROENCAPSULATED VIRUS ENVELOPE GLYCOPROTEINS WILL BE UTILIZED FOR A CLINICAL FIELD TRIAL FOR IMMUNOPROPHYLAXIS AGAINST NATURAL INFECTION FROM PARAINFLUENZA VIRUSES.

Principal Investigator:

Miroslav Novak
2059309384

Business Contact:

Small Business Information at Submission:

Secretech Inc
1025 18th St S #201 Birmingham, AL 35294

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No